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Marina Vasalaki, Saima Jamshaid Khan, Shah Karim, Gillian Adams, Himanshu Patel, M. Ashwin Reddy; Outcomes of laser treatment in infants with high-risk pre-threshold retinopathy of prematurity (ROP) in East London. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5907.
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To determine the outcomes of retinal ablative treatment in infants with high risk pre-threshold ROP treated at two level 3 neonatal units in East London.
Data from infants treated with diode laser between April 2006 and April 2012 were retrospectively collected and analysed against ETROP study standards. The primary outcome measure was structural findings at 6 months, 9 months and 2 years after laser treatment. The infants’ visual acuity and refractive state after laser treatment were also evaluated.
130 patients were treated with laser during this time. Long-term follow-up data was available in 40 patients (34 patients: Royal London Hospital, 6 patients: Homerton University Hospital) as many infants had been referred for treatment but were followed up in different units. Structural findings showed that 2 of 40 infants (5%) developed unilateral unfavourable structural outcomes within 2 years after laser treatment, which was within the ETROP standard (9%). Grating visual acuity results for 40 patients showed that 84% of infants achieved a BCVA of 6/15 or above, 2 years after laser treatment. Moreover, 54 % of infants had myopia and 73% of these were older than 2 years of age at last review. Their mean spherical equivalent was found to be approximately -1.75 D bilaterally.
Structural and functional outcomes of retinal ablative treatment in infants with high risk pre-threshold ROP are similar to ETROP outcomes. These results are helpful in informing parents of the likely outcome of laser treatment in babies requiring treatment for ROP.
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