Purchase this article with an account.
Akina Tanaka, Hidetaka Noma, Ryosuke Motohashi, Teruumi Minezaki, Kanako Yasuda, Masahiko Shimura; Dynamic change of aqueous concentrations of VEGF and its soluble receptors during the treatment of aflibercept in patients with age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2014;55(13):595.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To investigate the dynamic change of VEGF and its soluble receptors in the aqueous humor during the treatment of aflibercept in patients with age-related macular degeneration (ARMD)
Ten eyes of 10 patients with ARMD without any previous treatments were enrolled in this study and applied initial 3 monthly and additional 1 injections of aflibercept. Before each injection, aqueous humor was aspirated to prevent an increase of intraocular pressure, and the concentration of VEGF, soluble VEGF receptor-1 and -2 (sVEGFR-1, -2) in the aqueous humor was measured. Aqueous humor in the normal age-matched control subjects (n=10) were also collected at the time of cataract surgery. Central foveal thickness (CFT) and logMAR visual acuity (VA) in the eligible ARMD patients were also monitored.
During the clinical course, both CFT and VA were improved in all the eyes. At the initial injection, aqueous concentrations of VEGF was 47.8±27.6 pg/ml which was significantly higher than that obtained from control subjects. Aqueous sVEGFR-1, and sVEGFR-2 were 1.84±1.66, and 0.44±0.04 ng/ml, both of which showed no significant difference from the control ones. During the treatment of aflibercept, VEGF concentration was significantly decreased with time to 2.9±3.6 pg/ml at last visit, while both sVEGFR-1 and sVEGFR-2 were significantly increased with time to 54.9±7.2, and 2.5±0.56 ng/ml.
In ARMD patients, intravitreous injection of aflibercept not only reduce the aqueous concentrations of VEGF, but increase those of sVEGFR-1 and sVEGFR-2. Thus aflibercept affects the intraocular expression of VEGF receptors.
This PDF is available to Subscribers Only