April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
The developing optic nerve head in infantile idiopathic nystagmus and nystagmus associated to albinism
Author Affiliations & Notes
  • Ravi Purohit
    Ophthalmology Group, University of Leicester, Leicester, United Kingdom
  • Helena Lee
    Ophthalmology Group, University of Leicester, Leicester, United Kingdom
  • Aarti Patel
    Ophthalmology Group, University of Leicester, Leicester, United Kingdom
  • Viral Sheth
    Ophthalmology Group, University of Leicester, Leicester, United Kingdom
  • Gail Maconachie
    Ophthalmology Group, University of Leicester, Leicester, United Kingdom
  • Eleni Papageorgiou
    Ophthalmology Group, University of Leicester, Leicester, United Kingdom
  • Rebecca J McLean
    Ophthalmology Group, University of Leicester, Leicester, United Kingdom
  • Irene Gottlob
    Ophthalmology Group, University of Leicester, Leicester, United Kingdom
  • Frank A Proudlock
    Ophthalmology Group, University of Leicester, Leicester, United Kingdom
  • Footnotes
    Commercial Relationships Ravi Purohit, None; Helena Lee, None; Aarti Patel, None; Viral Sheth, None; Gail Maconachie, None; Eleni Papageorgiou, None; Rebecca McLean, None; Irene Gottlob, None; Frank Proudlock, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 5980. doi:https://doi.org/
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      Ravi Purohit, Helena Lee, Aarti Patel, Viral Sheth, Gail Maconachie, Eleni Papageorgiou, Rebecca J McLean, Irene Gottlob, Frank A Proudlock; The developing optic nerve head in infantile idiopathic nystagmus and nystagmus associated to albinism. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5980. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To use spectral domain hand-held optical coherence tomography (SD-HHOCT) to characterise the development of the optic nerve head (ONH) in infants between birth and seven years of age with infantile idiopathic nystagmus (IIN) and nystagmus associated to albinism, in comparison to normal controls.

Methods: 38 participants with IIN, 53 with albinism and 176 controls, aged between 0 and 7 years had optic nerves imaged using SD HH-OCT. The central B scan was identified as the point of the nerve with the deepest cup. Parameters included disk, cup and rim dimensions and peripapillary retinal thickness and retinal nerve fibre layer (RNFL) were correlated to log gestational age (logGA).

Results: There was a significant increase in disk diameter with logGA in all three groups (p<0.001) with no significant inter- group differences. Cup diameter also increased with logGA in albinism (p=0.009), but not in the IIN group. Consequently changes in cup to disk ratio with logGA were insignificant in all groups. The rim area was significantly greater in IIN than in controls (p=0.035), also showing a greater rate of increase with logGA than controls (p=0.036; IIN: r=0.615; Ctrl: r=0.230), mainly because of increase in the nasal rim. In contrast larger increase occurred in the temporal rim in albinism in relation to logGA (p=0.004). Temporal rim area was significantly thicker in albinism compared to controls (p=0.042), and increased at a faster rate (p=0.021). Nasal and temporal peripapillary retinal thickness was greater in IIN compared to controls (nasal: p=0.003; temporal: p=0.005) and increased at a faster rate (nasal: p=0.003; temporal: 0.005). In the albinism these changes were limited to temporal retinal thickness (compared to controls: p=0.015; interaction with logGA: p=0.023). Although RNFL changed with logGA there were no significant differences between the three groups.

Conclusions: We describe different patterns of the optic nerve development between the three groups. The IIN group shows greater rate of increase in neural tissue on nasal and temporal sides of the ONH with age with the greatest changes being observed for the nasal side. Only temporal neural tissue shows a significantly higher rate of thickening in the albinism group. These data show there are significant changes in the development of the optic nerve in infants with idiopathic infantile nystagmus and nystagmus associated to albinism.

Keywords: 629 optic nerve • 619 nystagmus • 556 infant vision  
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