April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Frequency of subretinal drusenoid deposits (SDD) in Older Eyes in Normal Macular Health or with Early or Intermediate Age-related Macular Degeneration (AMD)
Author Affiliations & Notes
  • David Neely
    UAB Department of Ophthalmology, Birmingham, AL
  • Mark E Clark
    UAB Department of Ophthalmology, Birmingham, AL
  • Carrie E Huisingh
    UAB Department of Ophthalmology, Birmingham, AL
  • Gerald McGwin
    UAB Department of Ophthalmology, Birmingham, AL
  • Richard M Feist
    UAB Department of Ophthalmology, Birmingham, AL
  • Yuhua Zhang
    UAB Department of Ophthalmology, Birmingham, AL
  • Cynthia Owsley
    UAB Department of Ophthalmology, Birmingham, AL
  • Christine A Curcio
    UAB Department of Ophthalmology, Birmingham, AL
  • Footnotes
    Commercial Relationships David Neely, None; Mark Clark, None; Carrie Huisingh, None; Gerald McGwin, None; Richard Feist, None; Yuhua Zhang, None; Cynthia Owsley, None; Christine Curcio, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 6005. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      David Neely, Mark E Clark, Carrie E Huisingh, Gerald McGwin, Richard M Feist, Yuhua Zhang, Cynthia Owsley, Christine A Curcio; Frequency of subretinal drusenoid deposits (SDD) in Older Eyes in Normal Macular Health or with Early or Intermediate Age-related Macular Degeneration (AMD). Invest. Ophthalmol. Vis. Sci. 2014;55(13):6005. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: SDD are extracellular lesions that confer risk for AMD progression independently from drusen, yet are misclassified or omitted altogether from grading systems based on color fundus photography, including those used for genetic association studies. We determined SDD frequency and optimal imaging modality in a sample of eyes in normal macular health or with early or intermediate AMD.

Methods: Patients ≥ 60 years old with either normal macular health or AMD were recruited from comprehensive ophthalmology clinics. Color fundus photographs, infrared (IR) and autofluorescence (AF) images, and SD-OCT volumes were obtained. Patients were stratified by the AREDS 9-step severity scale (PMID 162866100), the CARMS (PMID 16458093), and the Clinical Classification System (PMID 23332590). In each IR, SD-OCT, AF, and color image from a 96 patient convenience sample, SDD was graded as present, questionable, or absent. For each eye, a summary SDD classification considered SDD Present if present in SD-OCT and present or questionable in at least one en face modality; Questionable if questionable in SD-OCT and either questionable or absent in all en face modalities; and Absent if absent in SD-OCT and in all en face modalities. The distribution of summary classifications was determined relative to the 3 grading systems.

Results: SDD was judged Present, Questionable, and Absent in 18 (19%), 37 (39%), and 39 (41%), respectively, of 94 imaged Right eyes, and 16 (17%), 30 (32%), 44 (47%), respectively, in 90 imaged Left eyes. When present by SD-OCT, SDD was also present in 55% more Right Eyes and 88% more Left Eyes using IR than using AF. SDD was present in 18.2-34.5% of eyes with either early or intermediate AMD, and in 4.9-20.0% of normal eyes, depending on the eye and grading system. Up to 40% of SDD evaluations were considered questionable, at all stages.

Conclusions: This is the first examination of SDD frequency in eyes with early and intermediate AMD and those in normal macular health, all subject to imaging technologies suitable for SDD detection. IR in combination with SD-OCT revealed more eyes with SDD than AF in combination with SD-OCT.

Keywords: 412 age-related macular degeneration  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×