April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Correlation between changes in visual acuity and time in age-related macular degeneration
Author Affiliations & Notes
  • Juan Pablo Real
    Departamento de Farmacia-, Facultad de Ciencias Químicas-Universidad Nacional de Córdoba, Argentina. UNITEFA(CONICET)., Cordoba, Argentina
  • Santiago Palma
    Departamento de Farmacia-, Facultad de Ciencias Químicas-Universidad Nacional de Córdoba, Argentina. UNITEFA(CONICET)., Cordoba, Argentina
  • Gladys Granero
    Departamento de Farmacia-, Facultad de Ciencias Químicas-Universidad Nacional de Córdoba, Argentina. UNITEFA(CONICET)., Cordoba, Argentina
  • Claudio P Juarez
    Ophthalmology, Centro Privado de Ojos Romagosa SA - Fundación VER, Cordoba, Argentina
  • Jose D Luna Pinto
    Ophthalmology, Centro Privado de Ojos Romagosa SA - Fundación VER, Cordoba, Argentina
  • Footnotes
    Commercial Relationships Juan Pablo Real, None; Santiago Palma, None; Gladys Granero, None; Claudio Juarez, None; Jose Luna Pinto, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 602. doi:https://doi.org/
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    • Get Citation

      Juan Pablo Real, Santiago Palma, Gladys Granero, Claudio P Juarez, Jose D Luna Pinto; Correlation between changes in visual acuity and time in age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2014;55(13):602. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

Observe changes in visual acuity (VA) over time in patients with age related macular degeneration (AMD) from clinical diagnosis to first antiangiogenics treatment and after antiangiogenic loading doses to disease reactivation

 
Methods
 

A retrospective observational study was conducted. Patients with untreated wet ARMD, confirmed by fluorescein angiogram (FA) or optical coherence tomography (OCT) and a best corrected visual acuity (BCVA) of 20/40 to 20/320.The main outcome measures used were: the different delay times produced between indication for treatment (after initial and recurrence diagnosis) and intravitreal injection (initiation of loading dose and treatment dose for recurrence) with changes in BCVA produced along of this waiting time (WT).

 
Results
 

Eighty-Four eyes were included. The mean duration of initial WT was 87.5 days, the mean follow-up period was 1.81 years and 35% of patient had lost of VA compatible with recurrence criteria. Both WTs were significantly correlated (rinitial=0.60,p<0.01; rrecurrence=0.85,p<0.01) with BCVA changes. Although significant by either linear or polynomial regression analysis, according index of determination, in both cases changes in BCVA during WT were best described by nonlinear polynomial regression (figure).To analysis the impact of initial WT, the cohort was divided according percentiles p33.3 and p66,6 into 3 groups for their respective comparison. During initial WT, all groups showed a statistically significant reduction in BCVA, being significantly higher in the group 3 that also showed the smallest VA improvement after loading phase (LP). An association between this improvement and WT was found (Pearson coefficient -0.26).

 
Conclusions
 

VA changes as a function of time show a rapid loss of VA in the early times of the disease, slowing the velocity of loss after an AV of 20/200 approx hence showing an asymptotic behavior

  
Keywords: 412 age-related macular degeneration • 754 visual acuity • 688 retina  
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