Purchase this article with an account.
Mukhtar Bizrah, Omar Abdul Rahman Mahroo, Obeda Kailani, Talib Dar, Abhishek Nag, Juliet Thompson, Christopher J Hammond; Confirmation of association of axial length and young age with post-operative steroid-induced intraocular pressure rise in a large cataract cohort.. Invest. Ophthalmol. Vis. Sci. 2014;55(13):6027.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Post-operative intraocular pressure steroid induced (IOP) rise following cataract surgery has been shown to be associated with younger age and longer axial length in one cohort (Chang et al., J Cataract Refract Surg 2011). We sought to confirm whether such associations were discernible in a separate, larger cohort.
Electronic patient records of consecutive patients undergoing cataract surgery in a single eye department between June 2006 and December 2012 were reviewed. Right eyes only were included to avoid confounding effects of including both eyes of the same patient. Patients were excluded if pre-operative or post-operative IOP (typically 2 weeks post-surgery) was unavailable or if any operative complications occurred (with the exception of corneal epithelial abrasion). Patients with a pressure rise of 25% or more compared to baseline and in whom the post-operative IOP was 24 mm Hg or more were identified. Comparison was made between these patients and the remainder of the group in terms of age and axial length (unpaired t test).
Of 6508 consecutive right eye cataract operations over the period, 2256 eyes did not have either a pre or post-operative IOP entered into the electronic record. 107 eyes were recorded as having an intraoperative complication. A total of 4145 eyes were therefore included. Of these, 21 eyes developed an IOP rise according to the above criteria. The mean age (SD) of these patients was 69.8 (10.6) years and mean axial length was 25.11 (2.45) mm. For the remainder of the cohort, mean age and axial length were 75.7 (9.4) years and 23.55 (1.34) mm respectively. Differences between the groups were significant (p = 0.0042 for age and 1.26 x 10-7 for axial length). When patients were grouped by axial length, a trend to increasing pressure rise was seen with increasing axial length for eyes between 20 and 29 mm in length.
Our findings confirm the previously reported association of axial length and younger age with IOP rise in a separate, larger cohort. Future studies can probe the possible mechanisms underlying this interesting association, and may shed light on how IOP regulation is achieved. The findings may also have relevance to the widely reported association between myopia and glaucoma.
This PDF is available to Subscribers Only