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Toru Matsunaga, Tomomi Tashiro, Takao Sato, Toshinari Funaki, Akira Murakami; Development of Soft Contact Lens for Drug Delivery Using Zwitter Ionic Hydrogel. Invest. Ophthalmol. Vis. Sci. 2014;55(13):6050.
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© ARVO (1962-2015); The Authors (2016-present)
As drug delivery system device in the treatment of eye diseases, using soft contact lens (SCL) have been investigated and approached for a long time. However, the sustained and selective release of drug have not been secured because the interaction of SCL with the drug varies depending on the each characteristics. Furthermore, drug delivery system SCL (DDSSCL) should be kept the stable shape in order to ensure the vision correction. From our evaluation about the interaction of SCL with ophthalmic solutions, we have found the zwitter ionic material is stable in ophthalmic solutions. For the purpose of this study, as a base of material with the zwitter ionic hydrogel, we developed and evaluated the DDSSCL using an ion-exchange reaction.
By using a monomer having a quaternary ammonium salt group and a carboxyl group as ionic monomer, ionic hydrogel different in ration of each ionic monomer were produced and DDSSCL were produced to soak the ionic hydrogel in the drug solution. Disodium cromoglycate (DSCG) was used as a model drug because it has a long history for allergic conjunctivitis treatment drug. The produced DDSSCL was soaked in phosphate buffer and was observed the lens shape. In addition, released DSCG from the DDSSCL were measured with high pressure liquid chromatography in the every given time and evaluated the release behavior. Furthermore, the evaluation of DDSSCL in vivo measured DSCG concentration of tear in the every given time after wearing it on Japanese white rabbit eyes, and compared the data with the case of treatment by ophthalmic solutions.
The uptake quantity of DSCG for DDSSCL increased depending on the ration of the quaternary ammonium salt group and the release behavior was observed over 8 hours or more. In addition, DDSSCL having both ionic group were keep the shape, but it having only one ionic group were observed deformation. Moreover, DSCG concentration of tears were decreased in a short time after instillation, but they were kept more than 8 hours in DDSSCL wearing groups.
The DDSSCL as a base of material with the zwitter ionic hydrogel is useful device as having to ensure the vision correction and the high safety drug delivery system becasuse the device is possible sustained drug release and to keep the shape.
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