April 2014
Volume 55, Issue 13
ARVO Annual Meeting Abstract  |   April 2014
Risk factors for contact lens-related microbial keratitis: a case-control multicenter study
Author Affiliations & Notes
  • Tristan Bourcier
    Hôpitaux Universitaires de Strasbourg, Strasbourg, France
  • Sauer Arnaud
    Hôpitaux Universitaires de Strasbourg, Strasbourg, France
  • Footnotes
    Commercial Relationships Tristan Bourcier, None; Sauer Arnaud, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 6075. doi:
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      Tristan Bourcier, Sauer Arnaud, French Study Group for Contact Lenses related Microbial Keratitis; Risk factors for contact lens-related microbial keratitis: a case-control multicenter study. Invest. Ophthalmol. Vis. Sci. 2014;55(13):6075.

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      © ARVO (1962-2015); The Authors (2016-present)

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The most feared complication of contact lens (CL) wear is microbial keratitis (MK), even though its incidence remains low. This study aimed to identify the risk factors of CL-related MK in relation to individual patients’ risks and societal burdens.


A multicenter case-control study was designed. The CL-related MK subpopulation (Case) was compared to healthy CL wearers (Control) using a 52-item anonymous questionnaire designed to determine subject demographics and lens wear history. Univariate and multivariate logistic regression analyses were performed to compare both groups.


The study enrolled 750 cases and 750 controls, and revealed a higher risk for MK patients wearing soft CL, with cosmetic CL, with overnight wear, exceeding the CL- or the cleaning solution replacement delay, using a multipurpose cleaning solution. On the contrary, hyperopia, fitting and follow-up by an ophthalmologist, and respect of basic hygiene rules were protective against CL-related MK.


The infectious determinants were linked to the patient, type of lenses, hygiene routine, CL handling, cleaning solution, and storage case. This study aimed to highlight the increasingly CL-related MK, which likely occur due to lack of patient information regarding basic rules of hygiene, as well as CL care and handling.

Keywords: 477 contact lens • 573 keratitis • 464 clinical (human) or epidemiologic studies: risk factor assessment  

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