April 2014
Volume 55, Issue 13
ARVO Annual Meeting Abstract  |   April 2014
Symmetry of anatomic and functional response in bilateral diabetic macular edema treated with ranibizumab
Author Affiliations & Notes
  • Margaux Guillard
    ophthalmology, Lariboisière, Paris, France
  • Ali Erginay
    ophthalmology, Lariboisière, Paris, France
  • Bénédicte Dupas
    ophthalmology, Lariboisière, Paris, France
  • Ramin Tadayoni
    ophthalmology, Lariboisière, Paris, France
  • Pascale G Massin
    ophthalmology, Lariboisière, Paris, France
  • Footnotes
    Commercial Relationships Margaux Guillard, None; Ali Erginay, novartis (C); Bénédicte Dupas, novartis (C); Ramin Tadayoni, novartis (C); Pascale Massin, novartis (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 608. doi:
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      Margaux Guillard, Ali Erginay, Bénédicte Dupas, Ramin Tadayoni, Pascale G Massin; Symmetry of anatomic and functional response in bilateral diabetic macular edema treated with ranibizumab. Invest. Ophthalmol. Vis. Sci. 2014;55(13):608.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: To study symmetry of anatomic and functional response in bilateral diabetic macular edema (DME) treated by bilateral intra vitreal injection of ranibizumab (IVR).

Methods: 36 eyes from 18 patients treated with bilateral IVR were retrospectively reviewed. All patients received at least 3 monthly IVR injections over a five-months period. Favorable anatomic response was defined as a reduction of more than 10% of baseline central macular thickness (CMT) and favorable functional response was defined as an increase of best-corrected visual acuity (BCVA) of 5 letters or more on the ETDRS scale.

Results: A symmetric favorable anatomic response was observed in 16 (89%) patients, with an associated symmetric favorable functional response in 13 (72%) patients (i.e bilateral BCVA gain ≥ 5 letters of more). In the 3 remaining patients (17%), an asymmetric functional response was observed, i.e BCVA gain ≥ 5 letters was obtained in only one eye. An asymmetric anatomic response was seen in 2 (11%) patients. In the first case, no favorable functional response was observed in both eyes. Asymmetric anatomic response was explained by a local factor (lack of decrease in CMT in the eye with epiretinal membrane). In the second case, a favorable functional response was observed in the eye with favorable anatomic response, and poor anatomic and functional responses were observed in the fellow eye. Eye without anatomic response had a history of vitrectomy.

Conclusions: Anatomic response was symmetric in 89% of patients treated by bilateral IVR for bilateral macular edema, and symmetric favorable functional response was observed in 72% of cases. This may be of clinical interest in the decision to treat the fellow eye, in a disease where bilateral involvement is frequent.

Keywords: 499 diabetic retinopathy • 688 retina • 505 edema  

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