April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Multicenter Clinical Trial of Ultrasonic Circular Cyclo Coagulation in patients with Open-Angle Glaucoma: One Year Results
Author Affiliations & Notes
  • Florent Aptel
    Grenoble University Hospital, Grenoble, France
  • Philippe Denis
    Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France
  • Jean-François Rouland
    Hôpital Claude Huriez, CHRU de Lille, Lille, France
  • Jean-Philippe Nordmann
    Centre Hospitalier National des Quinze-Vingts, Paris, France
  • Yves Lachkar
    Institut du glaucome, Fondation Hôpital Saint-Joseph, Paris, France
  • Jean-Paul Renard
    Hôpital d'Instruction des Armées du Val de Grâce, Paris, France
  • Eric Sellem
    Centre Ophtalmologique Kléber, Lyon, France
  • Christophe Baudouin
    Centre Hospitalier National des Quinze-Vingts, Paris, France
  • Alain M Bron
    Hôpital Général, Dijon, France
  • Footnotes
    Commercial Relationships Florent Aptel, Alcon (F), Allergan (F), Eyetechcare (F), Novartis (F), Théa (F); Philippe Denis, None; Jean-François Rouland, None; Jean-Philippe Nordmann, None; Yves Lachkar, None; Jean-Paul Renard, None; Eric Sellem, None; Christophe Baudouin, None; Alain Bron, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 6170. doi:https://doi.org/
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      Florent Aptel, Philippe Denis, Jean-François Rouland, Jean-Philippe Nordmann, Yves Lachkar, Jean-Paul Renard, Eric Sellem, Christophe Baudouin, Alain M Bron; Multicenter Clinical Trial of Ultrasonic Circular Cyclo Coagulation in patients with Open-Angle Glaucoma: One Year Results. Invest. Ophthalmol. Vis. Sci. 2014;55(13):6170. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To evaluate the efficacy and safety of the Ultrasonic Circular Cyclo Coagulation (UC3) procedure with one year of follow-up.

Methods: Prospective non comparative interventional clinical study performed in 9 French glaucoma centers. Fifty-two eyes of 52 patients with open-angle glaucoma, intraocular pressure (IOP) > 21 mmHg, an average of 1.7 failed previous surgeries and an average of 3.7 hypotensive medications were insonified with a therapy probe comprising 6 piezoelectric transducers. The 6 transducers were activated, 24 patients (group 1) were treated with a 4 seconds exposure time for each shot and 28 patients (group 2) with a 6 seconds exposure time. Complete ophthalmic examinations were performed before the procedure, and at 1 day, 1 week, 1, 2, 3, 6 and 12 months after. Primary outcomes were surgical success (defined as IOP reduction from baseline ≥ 20% and IOP > 5mmHg) at the last follow-up visit, and vision-threatening complications. Secondary outcomes were mean IOP at each follow-up visits compared to baseline, medication use, complications, and re-interventions.

Results: IOP was significantly reduced in both groups (p<0.05), from a mean preoperative value of 30.3 ± 7.8 mmHg in group 1 and 29 ± 7.4 mmHg in group 2 to a mean value of 20.0 ± 6.9 mmHg in group 1 and 19.0 ± 6.7 mmHg in group 2 at last follow-up. Success (IOP reduction >20%) was achieved in 63.2% of eyes of the group 1 and 44% of eyes of the group 2 at last follow-up. Seven patients were ret-treated. No major intra- or post-operative complications occurred.

Conclusions: Ultrasonic Circular Cyclo Coagulation seems to be an effective and well-tolerated method to reduce intraocular pressure in patients with OAG. We found a lower efficacy with the higher dose.

Keywords: 427 aqueous • 455 ciliary body  
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