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Kaori Ueda, Akiyasu Kanamori, Yoshiko Matsumoto, Azusa Akashi, Yuko Yamada, Makoto Nakamura; Evaluation of circumpapillary retinal nerve fiber layer from nasal hemiretina. Invest. Ophthalmol. Vis. Sci. 2014;55(13):6215.
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© ARVO (1962-2015); The Authors (2016-present)
Circumpapillary retinal nerve fiber layer (cpRNFL) originating from temporal hemiretina mainly distributed at temporal-upper and lower area of optic disc. This characteristic projection is established and contributes the “double-hump” pattern of cpRNFL. However, the distribution of cpRNFL originating from nasal hemiretina is not well investigated. The purpose of study is to evaluate it in patients with band atrophy (BA) by compression optic neuropathy at chiasma.
Chiasmal compression predominantly affects the crossing nerve fibers and inner retinal layer in the nasal hemiretina. CpRNFL thickness was measured by 3D OCT-2000 (Topcon Inc.) in 53 BA eyes with temporal hemianopia due to optic chiasmal compression and 80 normal eyes. Any participants with nasal visual field loss were excluded. The average visual field sensitivity (VFS) of the temporal visual field in Humphrey visual field analyzer was expressed by 1/Lambert. In BA eyes, we analyzed the relationship between cpRNFL thickness in 12-clock sectors and VFS by regression analysis. Floor effect (FE) in each cpRNFL sector was set when temporal visual sensitivity was 0 and compared with the thickness of normal eyes.
In BA eyes, cpRNFL thicknesses in all sectors were statistically reduced compared with normal eyes. While the average cpRNFL thickness was 102.9µm in normal eyes, the average FE in BA eyes was 71.2µm. All cpRNFL sectors showed a significantly negative correlation with VFS. The reduction rates of FE in 12 sectors from normal eyes ranged from 16 to 52µm, among which 1 and 5 clock sectors particularly showed a high reduction rate.
CpRNFL originating from the nasal hemiretina was estimated to be about 30μm of entire cpRNFL. Furthermore, cpRNFL from the nasal hemiretina is considered to enter mainly nasal-upper and nasal-lower area of optic disc, and that might be similar to the distribution of cpRNFL from temporal hemiretina.
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