April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Characteristics of Normal Optic Nerve Development Using Hand-Held Ultra-High Resolution Spectral Domain Optical Coherence Tomography in Children and Young Adults.
Author Affiliations & Notes
  • Dr Patel
    Ophthalmology Group, University of Leicester, Leicester, United Kingdom
  • Ravi Purohit
    Ophthalmology Group, University of Leicester, Leicester, United Kingdom
  • Helena Lee
    Ophthalmology Group, University of Leicester, Leicester, United Kingdom
  • Viral Sheth
    Ophthalmology Group, University of Leicester, Leicester, United Kingdom
  • Gail Maconachie
    Ophthalmology Group, University of Leicester, Leicester, United Kingdom
  • Eleni Papageorgiou
    Ophthalmology Group, University of Leicester, Leicester, United Kingdom
  • Frank A Proudlock
    Ophthalmology Group, University of Leicester, Leicester, United Kingdom
  • Rebecca J McLean
    Ophthalmology Group, University of Leicester, Leicester, United Kingdom
  • Irene Gottlob
    Ophthalmology Group, University of Leicester, Leicester, United Kingdom
  • Footnotes
    Commercial Relationships Dr Patel, None; Ravi Purohit, None; Helena Lee, None; Viral Sheth, None; Gail Maconachie, None; Eleni Papageorgiou, None; Frank Proudlock, None; Rebecca McLean, None; Irene Gottlob, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 6235. doi:https://doi.org/
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      Dr Patel, Ravi Purohit, Helena Lee, Viral Sheth, Gail Maconachie, Eleni Papageorgiou, Frank A Proudlock, Rebecca J McLean, Irene Gottlob; Characteristics of Normal Optic Nerve Development Using Hand-Held Ultra-High Resolution Spectral Domain Optical Coherence Tomography in Children and Young Adults.. Invest. Ophthalmol. Vis. Sci. 2014;55(13):6235. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: Early development of the optic nerve has previously been limited to histology and fundus photography. This is the first study to characterise optic nerve morphology in healthy full term infants and young adults using ultra-high resolution spectral domain hand-held OCT (HH SD-OCT).

Methods: 178 infants and young adults aged between 1 day and 18 years of age were recruited to the study. All participants were over 37 weeks gestational age at birth with no known ocular or neurological concerns. Full ophthalmological examination and a HH SD-OCT scan (Bioptigen, 2.6µm axial resolution) were performed without sedation. Images were analysed using ImageJ software with the assessor masked. Optic nerve cup, disc and neuroretinal rim parameters along with peripapillary retinal thickness and retinal nerve fibre layer (RNFL) were quantified and correlated with log gestational age (logGA).

Results: The optic disc and cup diameters and areas increased linearly with logGA (p<0.001) with the result that cup / disc ratios of diameters did not significantly change with logGA (p=0.08). Nasal and temporal neuroretinal rim areas and nasal peripapillary RNFL also increased linearly with logGA (p=0.04, p=0.01 and p=0.08 respectively). In contrast temporal peripapillary RNFL demonstrated a marked initial decrease in thickness between birth and 90 weeks gestational age followed by a slow increase. Change in peripapillary retinal thickness was also linear (p<0.001).

Conclusions: This is the first study to describe optic nerve development of full-term infants and children using HH SD-OCT. We have demonstrated the temporal RNFL has a different course of development to other optic nerve parameters. Our results provide a normative database for further studies investigating optic nerve pathology.

Keywords: 629 optic nerve • 497 development • 757 visual development: infancy and childhood  
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