Purchase this article with an account.
Ari Kamei, Eiichiro Nagasaka; Multifocal Photopic Negative Response (mfPhNR) and Ganglion Cell-Inner Plexiform Layer Thickness (GCIPLT) in Patients with Optic Nerve Lesions. Invest. Ophthalmol. Vis. Sci. 2014;55(13):6236.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To evaluate the interrelation of mfPhNR and GCIPLT in all, superior and inferior in patients with optic nerve lesions.
Twelve eyes of twelve volunteers with normal vision and eighteen eyes of nine patients with optic nerve lesions including normal tension glaucoma (NTG) were tested. The mfPhNR was recorded with the VERIS Science System 5.0.4. The visual stimulus was made up of 37 hexagons in an approximately 40-degree visual field, Pseudo-randomly alternating between black (5cd/m2) and white (200cd/m2) on the CRT monitor. Burian-Allen ERG Electrodes, Adult-bipolar or Pediatric-bipolar, were used for this testing. The recording time was approximately 8 min. with dilated pupils having the best-corrected visual acuity. The band pass filter of the amplifier was set from 1 to 100 Hz. The amplification and stimulus frequency were set to 10000 and 9.41 Hz (8 frames) respectively. Each trace of the mfPhNR found in all, superior and inferior regions was analyzed in about 10 degrees. The GCIPLT was measured using the Cirrus HD-OCT. The GCIPLT in average, superior and inferior was applied for analysis.
There was a correlation between the amplitude of the mfPhNR and GCIPLT in overall (R=0.385651, P=0.037821) and in the superior (R=0.470078,P=0.011359). On the other hand, there was no correlation between the amplitude of the mfPhNR and GCIPLT in the inferior (R= 0.027809, P= 0.880958).
We presented previously that there was a strong correlation between the amplitude of mfPhNR and Retinal Nerve Fiber Layer Thickness. There was less correlation between the amplitude of mfPhNR and GCIPLT.
This PDF is available to Subscribers Only