April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Association of HTLV-1 uveitis with systemic inflammatory diseases and adult T cell leukemia
Author Affiliations & Notes
  • Koju Kamoi
    Ophthalmology, Tokyo Medical and Dental University, Tokyo, Japan
    Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
  • Yukiko Terada
    Ophthalmology, Tokyo Medical and Dental University, Tokyo, Japan
    Miyata Eye Hospital, Miyakonojo, Japan
  • Kazunori Miyata
    Miyata Eye Hospital, Miyakonojo, Japan
  • Manabu Mochizuki
    Ophthalmology, Tokyo Medical and Dental University, Tokyo, Japan
    Miyata Eye Hospital, Miyakonojo, Japan
  • Footnotes
    Commercial Relationships Koju Kamoi, None; Yukiko Terada, None; Kazunori Miyata, None; Manabu Mochizuki, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 6280. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Koju Kamoi, Yukiko Terada, Kazunori Miyata, Manabu Mochizuki; Association of HTLV-1 uveitis with systemic inflammatory diseases and adult T cell leukemia. Invest. Ophthalmol. Vis. Sci. 2014;55(13):6280.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: Human T cell lymphotropic virus type 1 (HTLV-1) is the first retrovirus described as a causative agent of human disease. HTLV-1 infection affects systemic tolerance and causes ocular inflammation, i.e. HTLV-1 uveitis (HU). The infection also causes adult T cell leukemia (ATL), which leads fatal condition. We investigate the association of HU with systemic inflammatory diseases and ATL through clinical survey.

Methods: The clinical records of 575 patients with uveitis between February 2012 and May 2013 at Miyata Eye Hospital (southern part of Japan), a referral eye center of the HTLV-1 highly endemic region, were retrospectively reviewed.

Results: The survey showed the second most clinical entity of uveitis was HU (10.6%), followed by Sarcoidosis. Median duration of disease was 9.5 years (0.5-24 years) in HU patients. Medical history of the HU patients revealed that 8 patients (13.1%) had previous history of Graves’ disease with hyperthyroidism. As for other complications, 6 patients (9.8%) developed HTLV-I- associated myelopathy, and 4 patients (6.6%) developed Rheumatoid arthritis. Other inflammatory complications (Interstitial pneumonitis and Sjögren's syndrome) were also seen in 2 patients. It is noteworthy that none of HU patients developed ATL in the survey.

Conclusions: It is revealed that a close relation between HU and systemic inflammatory complications, however, there was no association of HU with development of ATL. In addition to further clinical survey, basic research is needed to identify the reason why non-malignant /inflammatory T cells in HU hardly transform into malignant /leukemic T cells in ATL, which may clarify fundamental mechanisms of HTLV-1 infection.

Keywords: 463 clinical (human) or epidemiologic studies: prevalence/incidence • 557 inflammation  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×