April 2014
Volume 55, Issue 13
ARVO Annual Meeting Abstract  |   April 2014
Topical Tacrolimus in Thygeson Superficial Punctate Keratitis.
Author Affiliations & Notes
  • Maria Carolina Marquezan da Silva
    UNIFESP, São Paulo, Brazil
  • Heloisa M Nascimento
    UNIFESP, São Paulo, Brazil
  • Luiz Vieira
    UNIFESP, São Paulo, Brazil
  • Myrna Serapião
    UNIFESP, São Paulo, Brazil
  • Rubens Belfort, Jr.
    UNIFESP, São Paulo, Brazil
  • Denise de Freitas
    UNIFESP, São Paulo, Brazil
  • Footnotes
    Commercial Relationships Maria Carolina Marquezan da Silva, None; Heloisa Nascimento, None; Luiz Vieira, None; Myrna Serapião, None; Rubens Belfort, Jr., None; Denise de Freitas, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 6290. doi:
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      Maria Carolina Marquezan da Silva, Heloisa M Nascimento, Luiz Vieira, Myrna Serapião, Rubens Belfort, Jr., Denise de Freitas; Topical Tacrolimus in Thygeson Superficial Punctate Keratitis.. Invest. Ophthalmol. Vis. Sci. 2014;55(13):6290.

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      © ARVO (1962-2015); The Authors (2016-present)

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To present the topical tacrolimus outcomes in Thygeson Superficial Punctate Keratitis in 11 cases.


Retrospective case series, carried out at Paulista School of Medicine, São Paulo, Brazil. Medical records of 11 patients, diagnosed with Thygeson Superficial Punctate Keratitis, in use of Tacrolimus eye ointment 0,03%, were collected, in different clinics in São Paulo. The diagnosis was based on clinical symptoms and signs.


The age of patients ranged from 7 to 64 years and 7 were female. The average follow-up was 5 years. Visual acuity improved in 100% of patients, being equal to or better than 20/25 in both eyes of 73% of the patients; 27% had visual acuity between 20/30 and 20/50 in the both eyes before treatment and improved to 20/25 or better. Similarly 100% of the patients showed improvement of symtoms and signs (photophobia, foreign body sensation, tearing, and typical superficial punctate keratitis).


Topical Tacrolimus seems to be effective to control the symptoms and signs of patients with Thygeson Superficial Punctate Keratitis. Tacrolimus has the advantage of triggering fewer side effects compared to the use of topical corticoid, treatment of choice for patients with acute Thygeson Keratitis.

Keywords: 573 keratitis • 482 cornea: epithelium  

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