April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Improved Staining, Tear Film Breakup Time, and Dry Eye Severity Level Following a Six-Month Treatment of a Cohort of Dry Eye Patients in Norway
Author Affiliations & Notes
  • Jon Roger Eidet
    Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway
    The Norwegian Dry Eye Clinic, Oslo, Norway
  • Tor Paaske Utheim
    Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway
    The Norwegian Dry Eye Clinic, Oslo, Norway
  • Øygunn A Utheim
    Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway
    The Norwegian Dry Eye Clinic, Oslo, Norway
  • Xiangjun Chen
    The Norwegian Dry Eye Clinic, Oslo, Norway
    SynsLaser Kirurgi, Tromsø and Oslo, Norway
  • Aleksandar Stojanovic
    SynsLaser Kirurgi, Tromsø and Oslo, Norway
    Department of Ophthalmology, University Hospital of North Norway, Tromsø, Norway
  • Sten Ræder
    The Norwegian Dry Eye Clinic, Oslo, Norway
    SynsLaser Kirurgi, Tromsø and Oslo, Norway
  • Footnotes
    Commercial Relationships Jon Roger Eidet, 2The Norwegian Dry Eye Clinic (S); Tor Utheim, The Norwegian Dry Eye Clinic, Oslo, Norway (I); Øygunn Utheim, The Norwegian Dry Eye Clinic, Oslo, Norway (E); Xiangjun Chen, The Norwegian Dry Eye Clinic, Oslo, Norway (E); Aleksandar Stojanovic, None; Sten Ræder, The Norwegian Dry Eye Clinic, Oslo, Norway (E)
  • Footnotes
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Investigative Ophthalmology & Visual Science April 2014, Vol.55, 6302. doi:https://doi.org/
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      Jon Roger Eidet, Tor Paaske Utheim, Øygunn A Utheim, Xiangjun Chen, Aleksandar Stojanovic, Sten Ræder; Improved Staining, Tear Film Breakup Time, and Dry Eye Severity Level Following a Six-Month Treatment of a Cohort of Dry Eye Patients in Norway. Invest. Ophthalmol. Vis. Sci. 2014;55(13):6302. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To assess the effectiveness of treating dry eye disease (DED) patients according to the guidelines reported by the International Dry Eye WorkShop (DEWS) 2007.

 
Methods
 

All patients with symptoms of DED who contacted the Norwegian Dry Eye Clinic, with or without a doctor’s referral, were consecutively included in the study. The ophthalmological work-up included assessment of e.g. staining and tear film breakup time (TFBUT) and staging of dry eye disease based on dry eye severity level (DESL) at months 0, 1, 3 and 6. Choice of treatment was based on the DESL, according to the International DEWS 2007. Statistical analyses included repeated-measures ANOVA.

 
Results
 

Twenty-nine patients (8 men/21 women) with DED of mixed etiologies were included. Patient demographics were as follows: 20 to 39 years (3 patients), 40 to 59 (10 patients), 60 to 79 (12 patients) and 80 to 99 (4 patients). Mean McMonnies and Ocular Surface Disease Index questionnaire scores prior to treatment were 14.5 ± 4.6 and 18.4 ± 10.0, respectively. Vital staining decreased from 3.1 ± 2.8 at month 0 to 1.4 ± 1.4 at month 6 (P<0.001). TFBUT increased from 4.2 ± 2.2 at month 0 to 7.0 ± 4.5 at month 6 (P<0.001). DESL decreased from 2.4 ± 0.5 at month 0 to 1.7 ± 0.6 at month 6 (P<0.001). The changes in these three measurements were independent of age (below or above 60 years) and gender.

 
Conclusions
 

Significant improvements on key parameters for assessing DED (staining and TFBUT) and DESL were obtained after a six-month treatment of a Norwegian cohort of DED patients. Treatment was effective irrespective of patient gender or age. The dry eye guidelines from DEWS 2007 are an effective treatment strategy for dry eye disease.

 
Keywords: 479 cornea: clinical science  
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