April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Evaluation of Demoxoft Lipogel and Demoxoft Liquid efficacy and safety in patients with Demodex blepharitis.
Author Affiliations & Notes
  • Malgorzata Krajewska
    Ophthalmological Center Optimum, Warsaw, Poland
  • Jaromir Wasyluk
    Ophthalmological Center Optimum, Warsaw, Poland
    Eye Clinic, Military Institute of Avation Medicine, Warsaw, Poland
  • Maciej K Oseka
    Ofta Sp. z o.o., Warsaw, Poland
  • Aleksandra Sedzikowska
    Department of General BIology and Parasitology, Medical University of Warsaw, Warsaw, Poland
  • Beata Roman
    Verco Sp. z o.o., Warsaw, Poland
  • Emilia Jaremko
    Verco Sp. z o.o., Warsaw, Poland
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 6304. doi:
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      Malgorzata Krajewska, Jaromir Wasyluk, Maciej K Oseka, Aleksandra Sedzikowska, Beata Roman, Emilia Jaremko; Evaluation of Demoxoft Lipogel and Demoxoft Liquid efficacy and safety in patients with Demodex blepharitis.. Invest. Ophthalmol. Vis. Sci. 2014;55(13):6304.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: Demodex blepharitis is a significant problem in the daily practice of ophthalmologists. Patients with ocular demodecosis have an increased risk of ocular bacterial infections and their complications. Demodex spp. is highly resistanced against antibacterial, anti-inflammatory or combined ophthalmic medicines. It is a frequent cause of treatment failure, long-term treatment and the higher risk of side effects. The aim of this study was to evaluate the efficacy and safety of new combined products containing essential oil derived from Spanish Sage and Aloe Vera, olivem, fucogel, dexpanthenol, low weight hyaluronic acid (Demoxoft Lipogel 15 ml and Demoxoft Liquid 100 ml) in Demodex blepharitis patients.

Methods: Efficacy of the formulations was evaluated on the basis of questionnaire and slit lamp exam before and after 2 and 6 weeks of Demoxoft Lipogel and Demoxoft Liquid usage in 21 patients with Demodex blepharitis.

Results: Demoxoft Lipogel and Demoxoft Liquid led to a significant improvement in subjective (itching, foreign body sensation, eyelash lost or abnormal direction, pain) and objective (redness and swelling of eyelid margin, redness and swelling of conjunctiva, cylindrical dandruff, corneal erosions, mucus) symptoms of Demodex blepharitis. It was accompanied by a significant reduction in the number of eggs, larval and adult specimens examined under a microscope before and after Demoxoft Lipogel and Demoxoft Liquid treatment . During the survey, there were no side effects of both products.

Conclusions: Demoxoft Lipogel and Demoxoft Liquid significantly reduce the number of Demodex spp. in patients with Demodex blepharitis and improve its objective and subjective symptoms.

Keywords: 557 inflammation • 422 antibiotics/antifungals/antiparasitics • 526 eyelid  
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