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Stephen M Huddleston, Julie Calderwood, Mary E Hoehn; Comparing Morbidity Rates in Retinopathy of Prematurity Treated with Either Intravitreal Bevacizumab or Conventional Laser Therapy. Invest. Ophthalmol. Vis. Sci. 2014;55(13):6357.
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Controversy still exists regarding the safety profile of anti-vascular endothelial growth factor agents versus traditional laser therapy in the treatment of retinopathy of prematurity. With this in mind, we designed a study to compare morbidity markers between these two treatment groups.
The last ten patients treated with laser therapy and the last ten patients treated with bevacizumab for retinopathy of prematurity at our institution were identified, and their charts were retrospectively analyzed. Patients were excluded if they had received both modalities of treatment. Our morbidity markers included: number of days that ventilator support was required following treatment, length of hospital stay following treatment, and mortality.
Our preliminary results indicate that length of hospital stay following therapy was longer in patients receiving laser treatment compared to those receiving intravitreal bevacizumab (80 days versus 61 days). Two patients in the laser group required prolonged ventilator support following treatment compared to no patients in the bevacizumab group. Mortality was found to be equal in both groups.
Use of intravitreal bevacizumab for vision threatening retinopathy of prematurity did not result in increased length of hospital stay nor prolonged ventilator support following treatment when compared to traditional laser therapy, and mortality was found to be equal between our two treatment groups.
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