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Dafna Goldenberg, Michaella Goldstein, Pazit Pianka, Anat Loewenstein, Uri Soiberman; Preservation of the Photoreceptor Layer following Subthreshold Laser Treatment for Diabetic Macular Edema as Demonstrated by SD-OCT. Invest. Ophthalmol. Vis. Sci. 2014;55(13):6361.
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Subthreshold laser treatment of diabetic macular edema (DME) may have less deleterious effects on the photoreceptors than regular continuous wave laser. This study aimed to assess whether subthreshold laser causes a long-term damage to the retinal structures, as demonstrated by SD-OCT, and to evaluate its efficacy in obliterating retinal diabetic microaneurysms.
A retrospective study of eyes that were diagnosed with non-foveal involving DME and underwent subthreshold laser treatment with the Lumenis Novus SRT system. SD-OCT scans of treated retinal areas, performed prior to treatment and approximately 4 months following treatment, were assessed for changes in the continuity of the photoreceptor (PR) layer, the thickness of the PR-retinal pigment epithelium (RPE) layer, the retinal thickness at the treatment sites, and the diameter of the microaneurysms.
Nineteen eyes and 31 microaneurysms were included in this study. Following treatment, the continuity of the inner / outer segments junction of the PR was confirmed in all but two cases. The thickness of the PR-RPE layers was 72.32 ± 7.36 µm and 70.97 ± 7.27 µm prior to and following treatment, respectively (p=0.061). The retinal thickness at the treatment sites decreased from 398.65 ± 57.89 µm to 372.74 ± 60.4 µm (p<0.001). The mean axial diameter of the microaneurysms was 87.32 ± 27.45 µm and 6.68 ± 26.12 µm, respectively (p<0.001).
In this study, subthreshold laser treatment of retinal diabetic microaneurysms has been shown to be efficacious and safe, as demonstrated by SD-OCT.
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