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Wuli Jia, Fangfang Yan, Fang Hou, Zhong-Lin Lu, Chang-Bing Huang; qCSF in Clinical Applications: Efficient Characterization and Classification of Contrast Sensitivity Functions in Aging. Invest. Ophthalmol. Vis. Sci. 2014;55(13):762. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
Sensitivity to luminance changes, or contrast sensitivity, is a fundamental visual function. The contrast sensitivity function (CSF), delineating contrast sensitivity over a wide range of spatial frequencies, provides a comprehensive characterization of spatial vision and a sensitive test for many physiological and pathological processes. Precise CSF measurements using the conventional psychophysical methods often take a long time and are impractical for clinical applications in special populations. In the current study, we tested whether the newly developed qCSF method (Lesmes, et al, 2010), taking about five minutes, can rapidly, reliably, and effectively evaluate CSFs in the aging population.
Five young (age: 22.6±1.4 yrs) and eight old (age: 69.3±1.3 yrs) subjects participated in the experiment. All subjects had been screened for ophthalmological and mental diseases. They were tested using the conventional method that measures individual contrast thresholds in a number of spatial frequency conditions using the phi method (Kontsevich&Tyler, 1998), and the qCSF which combines Bayesian adaptive inference with an information gain strategy to directly estimate four parameters that defines the observer’s CSF.
Our results showed that the CSF derived from the qCSF method well matched with that from the traditional phi method (young: F(1,4)=5.442, p>0.05); old:F(1,7)=1.462, p>0.10)and the test-retest reliability were exceptionally great(young:F(1,4)=1.329, p>0.10); old: (F(1,7)=0.297, p>0.10).More importantly, the qCSF method is sensitive to the CSF difference between the young and old groups (F(1,11)=9.714, p<0.01).
Aging significantly degrades contrast sensitivity. TheqCSF method can reliably and effectively measure CSFs in the aging population.
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