April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Endothelial Cell Loss After Descemet’s Stripping Automated Endothelial Keratoplasty in Glaucoma Patients With Glaucoma Drainage Devices
Author Affiliations & Notes
  • Nina Ni
    Wills Eye Hospital, Philadelphia, PA
    Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA
  • Brian J Sperling
    Cataract and Cornea Associates, Langhorne, PA
  • Sadeer B Hannush
    Wills Eye Hospital, Philadelphia, PA
    Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA
  • Footnotes
    Commercial Relationships Nina Ni, None; Brian Sperling, None; Sadeer Hannush, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 890. doi:
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      Nina Ni, Brian J Sperling, Sadeer B Hannush; Endothelial Cell Loss After Descemet’s Stripping Automated Endothelial Keratoplasty in Glaucoma Patients With Glaucoma Drainage Devices. Invest. Ophthalmol. Vis. Sci. 2014;55(13):890.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To evaluate endothelial cell loss and graft failure rate after Descemet’s stripping automated endothelial keratoplasty (DSAEK) for corneal edema associated with endothelial dysfunction in eyes with glaucoma drainage devices.

Methods: A retrospective review of 20 cases performed by a single surgeon (S.B.H) on 17 eyes. Outcome measures included endothelial cell loss and graft failure.

Results: With a mean follow-up of 29.7 ± 17.1 months, endothelial cell loss was 49% ± 17% at postoperative month 3, 60% ± 16% at month 6, 62% ± 20% at month 12, and 72% ± 18% at month 18. The rate of graft failure was 35%, with most of these eyes requiring repeat endothelial keratoplasty or penetrating keratoplasty.

Conclusions: DSAEK in eyes with corneal edema secondary to endothelial dysfunction in the presence of glaucoma drainage devices is a successful procedure for visual rehabilitation. The incidences of intermediate term endothelial cell loss and graft failure are significant.

Keywords: 481 cornea: endothelium • 741 transplantation  
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