Purchase this article with an account.
KoEun Kim, Jin Wook Jeoung, Young Kook Kim, Bo Ram Seol, Ki Ho Park, Dong Myung Kim; In vivo imaging of lamina cribrosa defects in eyes with distinct patterns of glaucomatous retinal nerve fiber layer damage. Invest. Ophthalmol. Vis. Sci. 2014;55(13):903.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To investigate the frequency of focal abnormalities in lamina cribrosa (LC) in eyes with distinct patterns of glaucomatous retinal nerve fiber layer (RNFL) damage using swept-source optical coherence tomography (SS-OCT).
One hundred and ninety-six eyes of 119 subjects with localized RNFL defects, 34 eyes of 23 subjects with diffuse RNFL defects, and 174 eyes of 109 healthy subjects were reviewed. All subjects underwent stereoscopic optic disc photography and in vivo LC imaging using a 3-dimensional optic disc scanning protocol with a prototype SS-OCT (Topcon, Inc., Tokyo, Japan). Two masked graders evaluated serial en face images and 12 radial B-scans to detect focal LC defects.
In eyes with localized RNFL defects, the proportion of eyes with ≥1 LC defect was 61.7%, which was significantly higher than that with diffuse RNFL defects (23.5%) and without any RNFL defects (9.2%; all P <0.001). A total of 187 focal LC defects were found in eyes with localized RNFL defects (1.0 LC defect/eye), 10 in eyes with diffuse RNFL defects (0.3 LC defect/eye), and 17 in healthy eyes (0.1 LC defect/eye).
Focal LC defects were more frequently visible in eyes with localized RNFL defects than those with diffuse RNFL defects. Further investigations are needed to elucidate the pathogenic role of focal LC abnormalities in distinct patterns of glaucomatous RNFL damage.
This PDF is available to Subscribers Only