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Bo Ram Seol, Jin Wook Jeoung, Young Kook Kim, Ki Ho Park, Dong Myung Kim; Investigating the relationship between focal lamina cribrosa defects and myopia using swept-source optical coherence tomography (SS-OCT). Invest. Ophthalmol. Vis. Sci. 2014;55(13):905.
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To investigate the relationship between focal lamina cribrosa (LC) defects and myopia using swept-source optical coherence tomography (SS-OCT).
We retrospectively reviewed the medical records of patients who were examined using an SS-OCT system and evaluated myopia-associated factors such as the spherical equivalent (SE) and axial length (AXL). We examined 248 eyes to determine the SE and 124 eyes to determine the AXL. According to the SE value, the 248 eyes were categorized into 2 groups: myopic (109 eyes; <−0.5 diopters) and non-myopic (139 eyes; ≥-0.50 diopters). The myopic group was further classified into 2 groups: moderately myopic (83 eyes; -6.0 to -0.5 diopters) and highly myopic (26 eyes; <-6.0 diopters). According to the AXL value, the 124 eyes were also classified into 2 groups: average (82 eyes; <24.5 mm) and long (42 eyes; ≥24.5 mm); the long group was further classified into 2 groups: medium-long (24 eyes; 24.5-26.0 mm) and very long (18 eyes; ≥26.0 mm). The relationship between focal LC defects and the values of SE and AXL was then evaluated.
Out of the 248 eyes, 66 had focal LC defects. Focal LC defects were more prevalent in eyes of the myopic (P = 0.033) and long (P = 0.008) AXL groups. Furthermore, focal LC defects were found to be more prevalent in the medium-long (50.0%) AXL group than in the very long and average (33.7% and 20.8%, respectively; P = 0.017) groups. Although no statistically significant difference was observed, focal LC defects occurred more frequently in the highly myopic (38.5%) group than in the moderately myopic and non-myopic (31.3%, 21.6%, respectively; P = 0.100) groups.
The SS-OCT imaging demonstrates the 3D structure of LC and allows visualization of focal LC defects. Based on the findings of this study, focal LC defects are significantly associated with myopia.
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