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Ruojin Ren, Christopher C Teng, Sung Chul Park, Mugen Liu, Lam Lu, Gustavo V De Moraes, Jeffrey M Liebmann, Robert Ritch; Factors Associated with Anterior Chamber Volume and Iris Volume in Pigment Dispersion Syndrome. Invest. Ophthalmol. Vis. Sci. 2014;55(13):923.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate clinical factors associated with anterior chamber volume (ACV) and iris volume (IV) in eyes with pigment dispersion syndrome (PDS) with and without ocular hypertension or glaucoma (PG) using swept-source optical coherence tomography (SS-OCT).
In this cross-sectional study, each participant underwent SS-OCT (Casia SS-1000 OCT; Tomey, Inc., Nagoya, Japan) to obtain 128 volumetric high-resolution radial B-scans centered on the pupil center and a complete ophthalmologic examination including standard automated perimetry (SAP) and spectral-domain OCT retinal nerve fiber layer thickness (RNFLT). Trace lines of the anterior chamber and iris contour were reviewed by a glaucoma specialist and corrected if necessary. ACV and IV were analyzed using the SS-OCT’s built-in software. ACV and IV were correlated with the following demographic and clinical factors using a multivariate model: age, phakic refractive error, untreated intraocular pressure (IOP), central cornea thickness (CCT), SAP mean deviation (MD) and RNFLT.
20 eyes (10 patients; 4 women; mean age, 43±12 years), including 7 PDS eyes and 13 PG eyes, were included. Mean refractive error, central corneal thickness, and SAP mean deviation were -2.56±2.34D, 556.8±27.3µm, and -2.44±3.24dB, respectively (Table 1). Mean ACV was 239±29 mm3 (range, 194-297) and mean iris volume was 44±5 mm3 (range, 37 -54). Greater ACV was associated with higher IOP (p=0.03) and associated with worse SAP MD (p=0.04) and lower CCT (p=0.04). IV was not related to these factors (all p>0.05).
Greater ACV appears to be greater with higher IOP and worse visual field status in PDS and PG eyes. Greater ACV may be related to more frequent or wider iridozonular contact and enhanced pigment liberation.
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