April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Anterior segment structural analysis with optical coherence tomography in primary congenital glaucoma
Author Affiliations & Notes
  • Rita Anjos
    centro hospitalar lisboa central, Lisboa, Portugal
  • luisa vieira
    centro hospitalar lisboa central, Lisboa, Portugal
  • Mariana Cardoso
    centro hospitalar lisboa central, Lisboa, Portugal
  • Andre Vicente
    centro hospitalar lisboa central, Lisboa, Portugal
  • Luís Pinto
    centro hospitalar lisboa central, Lisboa, Portugal
  • Cristina Ferreira
    centro hospitalar lisboa central, Lisboa, Portugal
  • Ana Xavier
    centro hospitalar lisboa central, Lisboa, Portugal
  • Vitor Maduro
    centro hospitalar lisboa central, Lisboa, Portugal
  • Cristina Brito
    centro hospitalar lisboa central, Lisboa, Portugal
  • Footnotes
    Commercial Relationships Rita Anjos, None; luisa vieira, None; Mariana Cardoso, None; Andre Vicente, None; Luís Pinto, None; Cristina Ferreira, None; Ana Xavier, None; Vitor Maduro, None; Cristina Brito, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 934. doi:
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      Rita Anjos, luisa vieira, Mariana Cardoso, Andre Vicente, Luís Pinto, Cristina Ferreira, Ana Xavier, Vitor Maduro, Cristina Brito; Anterior segment structural analysis with optical coherence tomography in primary congenital glaucoma. Invest. Ophthalmol. Vis. Sci. 2014;55(13):934.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To analyse anterior segment structure using anterior segment optical coherence tomography (AS-OCT) in children with primary congenital glaucoma (PCG).

Methods: A prospective case-control study was conducted in children with PCG and without glaucoma (control group), followed in Pediatric Ophthalmology Section of Hospital Dona Estefânia, Centro Hospitalar de Lisboa Central. A complete ophthalmologic evaluation and AS-OCT (AC biometry protocol) were done.

Results: Twenty-seven eyes (17 children with PCG) and 22 eyes (11 children without glaucoma) were enrolled in this study. In PCG group were detected higher values of anterior chamber (AC) width and central depth (p<0,001), larger angle-opening distance at 500 (p<0,001) and 750μm (p=0,001), trabecular-iris space area at 500 and 750μm (p<0,001) and angle recess area at 500 (p<0,001) and 750μm (p=0,001). Iris was singificantly thinner at 500μm from the scleral spur (p=0,011), in the middle of the iris (p<0,001) and at the thickest part (p=0,001), and longer (p<0,001), in PCG group. Visual acuity (logMAR) and AC width were positively correlated (r=0,688; p<0,001). Other features found included iris hypoplasia and anterior displacement.

Conclusions: This first study in children with PCG suggests that AS-OCT is relatively easy to acquire, can help in clinical and surgical follow-up and be useful as prognostic factor.

Keywords: 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 420 anterior chamber  
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