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Heather Kayew Mak, Christopher Kai-Shun Leung; A 3-year prospective analysis of anterior chamber depth using the swept-source optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 2014;55(13):939.
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To measure the longitudinal changes in the anterior chamber depth (ACD) and angle width using a swept-source anterior segment optical coherence tomography (OCT) and investigate factors associated with the change in ACD over three years of follow-up.
A total of 42 eyes from 38 primary open-angle glaucoma patients followed for ≥3 years were analyzed. All eyes were phakic during the follow-up. The anterior segment was imaged by a swept-source anterior segment OCT (Casia SS-1000 OCT, Tomey, Nagoya, Japan) in the dark at the baseline and then in 3 years. ACD and angle width of the horizontal meridian were measured using the instrument software. Linear mixed models were used to examine the association between the change in anterior chamber depth and age, gender, axial length, pupil diameter change, and angle width parameters (angle opening distance, trabecular iris space area, and trabecular iris area).
The mean age, ACD, axial length, and angle opening distance at final visit were 51.3 years, 2.8mm, 24.9mm and 547.6µm, respectively. The mean ACD significantly decreased after three years (mean±SD: -34.6±7.8µm, p<0.001), but there were no significant changes in the angle width. The change in ACD was negatively associated with age (p=0.043). A younger age had a larger change in ACD. There were no significant associations between change in ACD and gender, axial length, or angle width parameters (p>0.082).
The mean ACD decreased with age, suggesting an anterior displacement of the anterior lens surface over time. Change in ACD was more obvious in patients with a younger age.
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