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John G Flanagan, Firdaus Yusof, Richard Cheng, Faryan Tayyari, Nadia Espahbodi, Lee-Anne Khuu, Yvonne M Buys, Graham Eric Trope, Christopher Hudson; The Relationship Between Retinal Nerve Fibre Layer Thickness and Total Retinal Blood Flow in Primary Open Angle Glaucoma. Invest. Ophthalmol. Vis. Sci. 2014;55(13):953.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the relationship between Doppler SD-OCT derived retinal blood flow (RBF) and the retinal nerve fiber layer (RNFL) thickness in patients with primary open angle glaucoma (POAG) and healthy age-matched controls.
Thirty three POAG patients (age, 65±8 years; Humphrey Field Analyzer, HFA, mean deviation, MD, -2.28±3.85) and 33 healthy controls (age, 63±5 years; HFA MD -0.48±1.56) were recruited. The Doppler SD-OCT retinal blood flow measurement was taken using the circum-papillary double circular scan protocol in the RTVue system (Optovue Inc., Freemont, CA, USA). A minimum of six RBF scans were acquired. Flow parameters were calculated only from the valid scans. Peri-papillary RNFL thickness was measured using RTVue’s RNFL scan protocol.
The total RBF in the POAG group was significantly lower than in the control group (group mean POAG RBF = 30.61±9.29µL/min; group mean control RBF = 40.68±11.32µL/min; p=<0.01). Superior and inferior RBF were also significantly lower in the POAG group (p=<0.01 for both superior & inferior RBF). The average RNFL thickness, superior and inferior RNFL thickness were significantly lower in the POAG group (p=<0.01). Linear regression analysis showed a significant positive correlation between the total RBF and average RNFL thickness (r=0.38, p=0.03), and the superior RBF and superior RNFL thickness (r=0.37, p=0.01). There was no correlation between the inferior RBF and RNFL thickness (r=0.30, p=0.09).
There was an association between thinning of the RNFL and reduced inner retinal perfusion in the eyes of patients with POAG.
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