Detection of glaucomatous progression by visual field testings and two types of optical coherence tomographies

Abstract

Purpose: To evaluate the rate of change of cpRNFL and mGCC thickness observed by 2 types of SD-OCT devices.

Methods: The subjects were prospectively enrolled at Kyoto University Hospital between April 2008 and September 2009. Standard automated perimetry (SAP) with the Humphrey Visual Field Analyzer (24-2 SITA, Carl Zeiss-Meditec, Dublin, CA, USA) and OCT examinations (RTVue-100 [Optovue, Fremont, CA, USA] and the SpectralisTM HRA+OCT system (Heidelberg Engineering, Heidelberg, Germany]) were performed every 3 months. The subjects examined at least 4 times during the course of this study were included in the analysis. Linear mixed model was conducted to evaluate the longitudinal trends of each measurement.

Results: One hundred and twenty five eyes of 87 patients (53 women) were finally included in this study. Age ranged from 21 to 71 years (47.14 ± 11.37 years). The average of mean deviation (MD) at baseline was -6.36 dB (95% CI -5.31 dB to -7.40 dB). Linear mixed models showed estimated average rate of SAP MD change per year was -0.20 dB /year (95% CI -0.31 dB/year to -0.10 dB/year). Significant negative trends over time were also detected for average cpRNFL (RTVue: -0.41 μm /year [95% CI -0.67 μm/year to -0.16 μm/year], Spectralis: -1.36 μm /year [95% CI -1.65 μm/year to -1.07 μm/year]), and macular GCC parameters (RTVue: -0.47 μm /year [95% CI -0.64 μm/year to -0.30 μm/year]).

Conclusions: Both visual field testing and morphological examinations detected significant glaucoma progression.

Keywords: 550 imaging/image analysis: clinical