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Kenji Suda, Masanori Hangai, Tomoko Hasegawa, Hiroshi Yamada, Yugo Kimura, Hideo Nakanishi, Noriyuki Unoki, Hanako Ohashi Ikeda, Tadamichi Akagi, Nagahisa Yoshimura; Detection of glaucomatous progression by visual field testings and two types of optical coherence tomographies. Invest. Ophthalmol. Vis. Sci. 2014;55(13):984. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the rate of change of cpRNFL and mGCC thickness observed by 2 types of SD-OCT devices.
The subjects were prospectively enrolled at Kyoto University Hospital between April 2008 and September 2009. Standard automated perimetry (SAP) with the Humphrey Visual Field Analyzer (24-2 SITA, Carl Zeiss-Meditec, Dublin, CA, USA) and OCT examinations (RTVue-100 [Optovue, Fremont, CA, USA] and the SpectralisTM HRA+OCT system (Heidelberg Engineering, Heidelberg, Germany]) were performed every 3 months. The subjects examined at least 4 times during the course of this study were included in the analysis. Linear mixed model was conducted to evaluate the longitudinal trends of each measurement.
One hundred and twenty five eyes of 87 patients (53 women) were finally included in this study. Age ranged from 21 to 71 years (47.14 ± 11.37 years). The average of mean deviation (MD) at baseline was -6.36 dB (95% CI -5.31 dB to -7.40 dB). Linear mixed models showed estimated average rate of SAP MD change per year was -0.20 dB /year (95% CI -0.31 dB/year to -0.10 dB/year). Significant negative trends over time were also detected for average cpRNFL (RTVue: -0.41 μm /year [95% CI -0.67 μm/year to -0.16 μm/year], Spectralis: -1.36 μm /year [95% CI -1.65 μm/year to -1.07 μm/year]), and macular GCC parameters (RTVue: -0.47 μm /year [95% CI -0.64 μm/year to -0.30 μm/year]).
Both visual field testing and morphological examinations detected significant glaucoma progression.
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