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Nicholas Faron, James Hoekel, Lawrence Tychsen; Corneal Endothelial Cell Density in Ametropic Children and Adolescents. Invest. Ophthalmol. Vis. Sci. 2014;55(13):991.
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© ARVO (1962-2015); The Authors (2016-present)
Endothelial cell density (ECD) is known to decrease with age in adulthood. Less is known about ECD in childhood, particularly in children with substantial ametropia and amblyopia.
ECD was measured (n = 244 eyes) by automated and manual counting methods from noncontact scans obtained using a Nidek CS4 Confocal Microscope. Children and adolescents age 4-20 years (mean 10.2 years) were imaged before pediatric refractive excimer laser or phakic IOL surgery performed for ametropic amblyopia.
Refractive error of myopes was an average -8.04 D (range -1 to -22.5) and of hyperopes +3.97 D (range +1.25 to 6.75) with mean cylinder 1.57 D. ECD was 3495 ± 244 cells/mm2 in 4yo’s and 3020 ± 220 in 20yo’s. ECD decreased an average 28 cells/mm2 per year of age (r2 = 0.76; p < .01). Substantial differences were not found in ECD between hyperopic and myopic children (p = .24). ECD was ~ 6% greater than that reported in normal children age 5-14 years using 1990 era technology.
Highly ametropic and amblyopic children have ECD comparable to that reported previously in a population of normal children. ECD decreases in quasi-linear fashion throughout the first two decades of life.
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