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Balwantray C Chauhan, Masanori Hangai, Aiko Iwase, Toru Nakazawa, Kazuhisa Sugiyama, Hidenobu Tanihara, Goji Tomita, Yasuo Yanagi, Claude F Burgoyne, Makoto Araie; Bruch’s Membrane Opening-Based Neuroretinal Rim Width and Retinal Nerve Fibre Layer Thickness in a Normal Japanese Population. A Multi-Centre Study. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1014.
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© ARVO (1962-2015); The Authors (2016-present)
We characterised Bruch’s membrane opening minimum rim width (BMO-MRW) and peripapillary retinal nerve fibre layer thickness (RNFLT) and modelled their variability on a range of ocular and demographic parameters.
Approximately the same number of adults in each decade group was enrolled in 7 Japanese centres. Inclusion criteria were: (1) normal ocular and visual field exam; (2) visual acuity ≥ 6/12 and (3) refraction within ±6 D and 2 D astigmatism. SD-OCT (Spectralis, Heidelberg Engineering) images of the optic nerve head (24 radial scans) and peripapillary retina (3.5 mm diameter) centred on BMO were acquired relative to the eye-specific fovea to BMO centre (FoBMO) axis. Variation of BMO-MRW and RNFLT was analysed with respect to age, sectors relative to FoBMO axis, BMO area and axial length. These data were contrasted to a Caucasian database of 246 subjects (Chauhan et al., 2014).
One eye of 275 subjects with median (range) age of 52.3 (20.3 to 89.1) years was included in the study. The median (range) FoBMO angle and BMO area was -7.2° (-17.4° to +2.2°) and 2.0 (1.2 to 3.8) mm2, respectively. There was a significant age-related loss of both global mean BMO-MRW and RNFLT (Fig. 1) with respective rates of 1.02 µm/y and 0.15 µm/y after adjusting for BMO area. Age and BMO area explained ~21% of the variation in global mean BMO-MRW and ~17% in global mean RNFLT. BMO-MRW was significantly thinner in Japanese compared to Caucasians, while the RNFLT was thicker (P < 0.01 for both). While there were no differences in the age-related loss of either global mean BMO-MRW or RNFLT (P > 0.15), the sectoral pattern of age-related BMO-MRW loss in the two populations was uncorrelated (ρ = -0.01, P = 0.97, Fig. 2). In contrast, the pattern of age-related RNFLT loss was highly correlated (ρ = 0.89, P < 0.01, Fig. 2).
(1) There was a significant age-related loss of both BMO-MRW and RNFLT in a normal Japanese population. (2) Global rates of age-related loss were similar in Japanese and Caucasians but there were differences in the mean BMO-MRW and RNFLT values and also in the sectoral pattern of their loss. (3) The notable contrast between the two populations may help explain different susceptibilities to structural glaucomatous damage.
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