June 2015
Volume 56, Issue 7
ARVO Annual Meeting Abstract  |   June 2015
Bruch’s Membrane Opening-Based Neuroretinal Rim Width and Retinal Nerve Fibre Layer Thickness in a Normal Japanese Population. A Multi-Centre Study
Author Affiliations & Notes
  • Balwantray C Chauhan
    Ophthalmology & Visual Sciences, Dalhousie University-DAL-11762, Halifax, NS, Canada
  • Masanori Hangai
    Saitama Medical University, Saitama, Japan
  • Aiko Iwase
    Tajimi Iwase Eye Clinic, Tajimi, Japan
  • Toru Nakazawa
    Tohoku University, Sendai, Japan
  • Kazuhisa Sugiyama
    Kanazawa University, Kanazawa, Japan
  • Hidenobu Tanihara
    Kumamoto University, Kumamoto, Japan
  • Goji Tomita
    Toho University, Tokyo, Japan
  • Yasuo Yanagi
    University of Tokyo, Tokyo, Japan
  • Claude F Burgoyne
    Devers Eye Institute, Portland, OR
  • Makoto Araie
    University of Tokyo, Tokyo, Japan
  • Footnotes
    Commercial Relationships Balwantray Chauhan, Allergan (C), Heidelberg Engineering (F); Masanori Hangai, Heidelberg Engineering (F); Aiko Iwase, Heidelberg Engineering (F); Toru Nakazawa, Heidelberg Engineering (F); Kazuhisa Sugiyama, Heidelberg Engineering (F); Hidenobu Tanihara, Heidelberg Engineering (F); Goji Tomita, Heidelberg Engineering (F); Yasuo Yanagi, Heidelberg Engineering (F); Claude Burgoyne, Heidelberg Engineering (F); Makoto Araie, Heidelberg Engineering (F)
  • Footnotes
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Investigative Ophthalmology & Visual Science June 2015, Vol.56, 1014. doi:
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      Balwantray C Chauhan, Masanori Hangai, Aiko Iwase, Toru Nakazawa, Kazuhisa Sugiyama, Hidenobu Tanihara, Goji Tomita, Yasuo Yanagi, Claude F Burgoyne, Makoto Araie; Bruch’s Membrane Opening-Based Neuroretinal Rim Width and Retinal Nerve Fibre Layer Thickness in a Normal Japanese Population. A Multi-Centre Study. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1014.

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      © ARVO (1962-2015); The Authors (2016-present)

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We characterised Bruch’s membrane opening minimum rim width (BMO-MRW) and peripapillary retinal nerve fibre layer thickness (RNFLT) and modelled their variability on a range of ocular and demographic parameters.


Approximately the same number of adults in each decade group was enrolled in 7 Japanese centres. Inclusion criteria were: (1) normal ocular and visual field exam; (2) visual acuity ≥ 6/12 and (3) refraction within ±6 D and 2 D astigmatism. SD-OCT (Spectralis, Heidelberg Engineering) images of the optic nerve head (24 radial scans) and peripapillary retina (3.5 mm diameter) centred on BMO were acquired relative to the eye-specific fovea to BMO centre (FoBMO) axis. Variation of BMO-MRW and RNFLT was analysed with respect to age, sectors relative to FoBMO axis, BMO area and axial length. These data were contrasted to a Caucasian database of 246 subjects (Chauhan et al., 2014).


One eye of 275 subjects with median (range) age of 52.3 (20.3 to 89.1) years was included in the study. The median (range) FoBMO angle and BMO area was -7.2° (-17.4° to +2.2°) and 2.0 (1.2 to 3.8) mm2, respectively. There was a significant age-related loss of both global mean BMO-MRW and RNFLT (Fig. 1) with respective rates of 1.02 µm/y and 0.15 µm/y after adjusting for BMO area. Age and BMO area explained ~21% of the variation in global mean BMO-MRW and ~17% in global mean RNFLT. BMO-MRW was significantly thinner in Japanese compared to Caucasians, while the RNFLT was thicker (P < 0.01 for both). While there were no differences in the age-related loss of either global mean BMO-MRW or RNFLT (P > 0.15), the sectoral pattern of age-related BMO-MRW loss in the two populations was uncorrelated (ρ = -0.01, P = 0.97, Fig. 2). In contrast, the pattern of age-related RNFLT loss was highly correlated (ρ = 0.89, P < 0.01, Fig. 2).


(1) There was a significant age-related loss of both BMO-MRW and RNFLT in a normal Japanese population. (2) Global rates of age-related loss were similar in Japanese and Caucasians but there were differences in the mean BMO-MRW and RNFLT values and also in the sectoral pattern of their loss. (3) The notable contrast between the two populations may help explain different susceptibilities to structural glaucomatous damage.  



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