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Edward Dervan, William Huxley Morgan, Anmar Abdul-Rahman, Dao-Yi Yu, Martin Hazelton, Brigid Betz-Stablein, Christopher Lind, Geoff Chan, Johnathan Lam; Tissue small vessel pulse amplitude differentiates between the cup, neuroretinal rim and retina in normal eyes. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1020.
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© ARVO (1962-2015); The Authors (2016-present)
<br /> Optic disk venous pulsation is a common and useful sign. We explored the presence and distribution of tissue small vessel pulsation in the optic cup, neuroretinal rim and retina in normal subjects to discern if features may be used to differentiate the neural tissue from non-neural tissue in the optic disk.
<br /> We used a novel technique utilizing high resolution video recordings of the optic disk and retina, timed to the cardiac cycle, that measures the fluctuating haemoglobin light absorption during pulsation. This produces a densitometry map containing the amplitude of pulsation at individual pixel points. This was correlated with images segmented into neuroretinal rim, retina, optic cup and retinal tissue by an independent observer. All visible retinal vessels were excluded from the analysis.
<br /> The video recordings of 6 normal eyes from 6 subjects were analyzed. We used a linear mixed model comparing the amplitude between 3 regions, allowing for distance from the disk centre and including a random factor to account for multiple measurements from individual patients. There was a significant difference in pulse amplitude between the cup (mean 1.35 ± SD 1.26) and the neuroretinal rim (mean 2.33 ± SD 1.35)(p=0.0000) and the retina (mean 2.36 ± SD 1.45)(p=0.0000) and also between the retina and neuroretinal rim (p=<0.001).
<br /> Tissue small vessel pulse amplitudes are significantly lower in the disk cup compared to neuroretinal tissue. This feature may be useful in following changes in glaucoma and other optic neuropathy patients.
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