June 2015
Volume 56, Issue 7
ARVO Annual Meeting Abstract  |   June 2015
Glaucoma Structural Progression by using Heidelberg Retina Tomograph (HRT)
Author Affiliations & Notes
  • Michele M Iester
    DiNOGMI, University of Genoa, Genova, Italy
  • Laura Gil Aribas
    DiNOGMI, University of Genoa, Genova, Italy
    University Eye Clinic, Siena, Italy
  • Carlo Enrico Traverso
    DiNOGMI, University of Genoa, Genova, Italy
  • Andrea Perdicchi
    St Andrea Hospital, Roma, Italy
  • Paolo Frezzotti
    University Eye Clinic, Siena, Italy
  • Antonio Ferreras
    University Eye Clinic, Siena, Italy
  • Footnotes
    Commercial Relationships Michele Iester, None; Laura Gil Aribas, None; Carlo Traverso, None; Andrea Perdicchi, None; Paolo Frezzotti, None; Antonio Ferreras, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 1021. doi:
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      Michele M Iester, Laura Gil Aribas, Carlo Enrico Traverso, Andrea Perdicchi, Paolo Frezzotti, Antonio Ferreras; Glaucoma Structural Progression by using Heidelberg Retina Tomograph (HRT) . Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1021.

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      © ARVO (1962-2015); The Authors (2016-present)

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Glaucoma progression analysis provided by Heidelberg retina tomography (HRT), the topographic change analysis (TCA), is based on the topographic change from baseline in the optic disc (ONH) and the peripapillary area. The purpose of this study was to compare structural progression by using different HRT parameters.


This is a retrospective longitudinal study. Thirty-two glaucomatous patients were enrolled into this study. All the included patient had to have a HRT follow-up of at least 3 years and 2 good quality HRT scans acquired at each visit. All the patients had at least 6 visual field examinations by Humphrey Field Analyzer in the last years and all of them had a visual field progression defined as a significant (p<0.01) VFI slope. Structural progression was evaluated by using cup shape measure (CSM), rim area (RA), rim volume (RV), TCA cluster area (CA), TCA cluster volume (CV). Data were analyzed by ANOVA test and Pearson’s r coefficient correlation.


During the follow-up, CSM, RV and RA did not show any significant change, the mean Pearson’s r coefficient was 0.06, -0.02 and -0.34, respectively. However, when only the correlation with a r > 0.25 was considered, the r coefficient improved to 0.58, -0.54, -0.74, respectively. When TCA CA and CV were assessed, a significant (p<0.001) change was found among the baseline and the follow-up examinations. The mean value of the Pearson’s r coefficient was 0.86 and 0.81, respectively.


TCA CA and CV showed the highest capacity to detect glaucomatous structural changes.


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