June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Steady-State Pattern Electroretinogram (ssPERG) Fixed Protocol Reference Ranges of Healthy Eyes.
Author Affiliations & Notes
  • Anna Shengelia
    Ophthalmology, New York Glaucoma Research Institute, New York, NY
  • Peter H Derr
    Diopsys Inc., Pine Brook, NJ
  • Alberto Gonzalez-Garcia
    Diopsys Inc., Pine Brook, NJ
  • Mark Ghassibi
    Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY
    George Washington University School of Medicine and Health Sciences, Washington, DC
  • Jason L Chien
    Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY
    George Washington University School of Medicine and Health Sciences, Washington, DC
  • Celso Tello
    Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY
    Ophthalmology, Manhattan Eye, Ear and Throat Hospital, Hofstra North Shore-LIJ School of Medicine, New York, NY
  • Robert Ritch
    Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY
    Ophthalmology, New York Medical College, Valhalla, NY
  • Footnotes
    Commercial Relationships Anna Shengelia, None; Peter Derr, Diopsys Inc. Pine Brook, NJ (E); Alberto Gonzalez-Garcia, Diopsys Inc. Pine Brook, NJ (E); Mark Ghassibi, None; Jason Chien, None; Celso Tello, Diopsys Inc. Pine Brook, NJ (C); Robert Ritch, Diopsys Inc. Pine Brook, NJ (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 1030. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Anna Shengelia, Peter H Derr, Alberto Gonzalez-Garcia, Mark Ghassibi, Jason L Chien, Celso Tello, Robert Ritch; Steady-State Pattern Electroretinogram (ssPERG) Fixed Protocol Reference Ranges of Healthy Eyes.. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1030. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose
 

To establish reference ranges from healthy subjects for the Steady State Pattern Electroretinogram (ssPERG) Fixed Protocols responses.

 
Methods
 

60 healthy eyes (60 subjects) were randomly selected. Inclusion criteria were the following: best corrected visual acuity 20/30 or better, spherical refraction within ±5.00 D, cylinder correction within ±3.00 D, normal Standard Automated Perimetry, normal slit lamp biomicroscopy, intraocular pressure ≤22 mmHg, normal stereoscopic disc photos, normal retinal nerve fiber layer (RNFL) thickness by optical coherence tomography (OCT), normal dilated fundus examination. ssPERGs were recorded using the Diopsys NOVA System (Diopsys, Inc. Pine Brook, NJ). Each eye was stimulated with the contrast sensitivity and the concentric field protocols. Test duration was 30 seconds/eye and each test resulted in a magnitude and magnitudeD response. Each response’s Magnitude, MagnitudeD and the MagnitudeD/Magnitude ratio was evaluated. Reference ranges were calculated for the Magnitude and MagnitudeD parameters for both protocols. The reference ranges were validated for normality of the residuals (Observed values - Predicted values) across the entire age range and for three equal sized subgroups based on age.

 
Results
 

Study population demographics were: 31.7% male; 68.3% female; 65.0% Caucasian; 10.0% African American; 10.0% Hispanic; and 15.0% Asian. The age range was 25 to 86 years old. The Magnitude was not significantly affected by the age (p=0.098). However, age did have an effect on the MagnitudeD parameter (p=0.004). The reference ranges with ±95% CI are as follows: Magnitude (Predicted) = 1.604 - 0.006 * Age, Magnitude (±95% CI) = 1.604 - 0.006 * Age (±1.96 * 0.39, MagnitudeD (Predicted) = 1.615 - 0.012 * Age, Magnitude (±95% CI) = 1.615 - 0.012 * Age (±1.96 * 0.43.

 
Conclusions
 

The ssPERG fixed protocol reference ranges with (±95CI) will provide researchers and clinicians the ability to compare a healthy subject or patient’s ssPERG results to an age adjusted mean value.

 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×