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Masamoto Aose, Hiroyuki Matsushima, Kouichiro Mukai, Mayumi Nagata, Norihito Gotoh, Tadashi Senoo; Experimental analysis of light scatterings in intraocular lenses. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1071. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
Recently, phase separations of acrylic materials (glistening and whitening (sub-surface nano glistenigs)) sometimes picked up as complications after cataract surgeries. The glistening and whitening increase light scattering. In this study, light scatterings of intraocular lenses (IOLs) were evaluated using rabbit eyes.
Eyes of 8 weeks albino rabbits weighting 2 kg had phacoemulsification in 2.4mm corneal insertion, after that, six types of hydrophobic acrylic IOLs (SN60WF before changing of IOL production process by Alcon (J group), SN60WF after changing of IOL production process by Alcon (Q group), ZCB00 AMO (Z group), AN6K Kowa (A group), NX-60 Santen (N group) and SP2 HOYA (S group)) were implanted. After 6 months post operation, the IOLs were extracted and cleaned to remove attachment proteins. The IOLs were placed in our model eye maintaining a constant temperature. The surface and inner light scatterings of the IOLs were imaged and analyzed with an anterior segment analyzer (EAS-1000, NIDEK). The intensity of light scattering was quantified in a selected area of surface or inner of IOL using densitometry. To measure the increasing rate of the light scatterings, these unused IOLs were also quantified.
The surface light scattering in J group was 22.0 ± 8.5 CCT, that in Q group was 21.5 ± 5.7 CCT, that in Z group was 10.3 ± 2.9 CCT, that in A group was 9.7 ± 3.4 CCT, that in N group was 22.7 ± 4.8 CCT, and that in S group was 4.0 ± 4.4 CCT. The increasing rate of the surface light scattering in J group was 3.8 ± 1.5, that in Q group was 3.3 ± 0.9, that in Z group was 2.2 ± 0.6, that in A group was 1.9 ± 0.7, that in N group was 1.7 ± 0.4, and that in S group was 1.2 ± 0.7. The increasing rate of the surface light scattering in J and Q groups was significantly higher than that in other groups (P<.05).
The light scatterings of hydrophobic acrylic IOLs were increased; however, the increasing rates of them were different.
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