June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Ocular straylight in the normal pseudophakic eye
Author Affiliations & Notes
  • Grzegorz Labuz
    Rotterdam Ophthalmic Institute, Rotterdam, Netherlands
    Facultad de Óptica y Optometría, Universidad de Murcia, Murcia, Spain
  • Nicolaas J. Reus
    Department of Ophthalmology, Amphia Hospital, Breda, Netherlands
  • Thomas J T P Van Den Berg
    Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, Netherlands
  • Ivan Marin-Franch
    Departamento de Óptica, Facultad de Física, Universitat de València, València, Spain
  • Footnotes
    Commercial Relationships Grzegorz Labuz, None; Nicolaas Reus, None; Thomas Van Den Berg, The Royal Netherlands Academy of Arts and Sciences (P); Ivan Marin-Franch, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 1078. doi:
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      Grzegorz Labuz, Nicolaas J. Reus, Thomas J T P Van Den Berg, Ivan Marin-Franch; Ocular straylight in the normal pseudophakic eye. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1078.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

It is well known that the ocular straylight gradually increases with age in normal phakic eyes. A normal reference curve has been defined for phakic eyes. However, the crystalline lens replacement causes considerable change in straylight, which also modifies the steepness of its increase with age. The purpose of this study was to determine a pseudophakic norm for straylight as a new reference. In addition, the proposed model was tested for its predictability of the effect of lens replacement on straylight improvement.

 
Methods
 

A retrospective cross-study data analysis was performed to evaluate changes in intraocular scatter upon crystalline lens exchange. The postoperative results were used to define the norm for straylight in pseudophakia with simple linear regression. Linearity was assessed with a loess fit. The normative limits were obtained using quantile regression. The straylight improvement following lens replacement was assessed based on individual pre- and postoperative values. Orthogonal regression was used to determine the break-even point (BEP) with age affect.

 
Results
 

The pseudophakic norm was based on 1533 eyes from 13 studies. The new reference as well as the individual postoperative straylight values are presented in Figure 1A. The outcomes of loess fit and quantile regression are shown in Figures 1B and 1C respectively. The straylight improvement as a function of preoperative value is presented in Figure 2. The BEP increase with subject age is shown with the red line in Figure 1A.

 
Conclusions
 

We developed a norm for straylight in the pseudophakic eye that differs from the previously published norm for the phakic eye. The loess fit shows that the straylight-age dependency in pseudophakia is no longer logarithmic but linear. Moreover, the BEP values are very close to the reference line (Figure 1A). Therefore, the established reference might be considered as a predictive feature to improve the decision-making process before crystalline lens exchange.  

 
Intraocular straylight as a function of age in pseudophakic eyes. A) The new straylight norm (solid black line) with 95% prediction interval (dashed lines). The red line shows the BEP-age dependency. B) The loess fit of the reference data. C) The quantile regression limits for the 90th, 95th, and 98th percentiles.
 
Intraocular straylight as a function of age in pseudophakic eyes. A) The new straylight norm (solid black line) with 95% prediction interval (dashed lines). The red line shows the BEP-age dependency. B) The loess fit of the reference data. C) The quantile regression limits for the 90th, 95th, and 98th percentiles.
 
 
Improvement of straylight upon lens exchange. The solid lines corresponds to the age range 40-50 years (left) and 80-90 years (right).
 
Improvement of straylight upon lens exchange. The solid lines corresponds to the age range 40-50 years (left) and 80-90 years (right).

 
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