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Müller Gonçalves Urias, Helio Francisco Shiroma, Eduardo B Rodrigues, Michel Eid Farah; Comparative study between lidocaine gel 2% and 5% for ophthalmic procedures. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1192.
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© ARVO (1962-2015); The Authors (2016-present)
To compare the anesthetic efficacy of lidocaine gel 2% and 5% on the ocular surface in healthy subjects.
A prospective, randomized, double-blind study was carried out by spraying lidocaine gel, at a concentration of 2% or 5% in each eye, of a healthy reasearch group. The pain during instillation and conjunctival clamping were evaluated on the fifth and tenth minute after the application of the gel. The break-up time of the tear film was also measured and the degree of corneal conjunctival dyeing was rated according to the Oxford scale.
Eighty eyes of 40 patients were evaluated. The groups were similar in gender, with a mean age of 48 ± 16.26 years. The pain caused by instillation was found to be higher in the group using lidocaine gel 5 % (p = 0.092). Pain recorded at conjunctival clamping was lower in lidocaine 5 % (p = 0.564) in both the fifth the tenth minute (p <0.001). The majority of patients (80 %) had no corneal conjunctival dyeing. They were classified in grades I (16.25 %) and II (3.75 %) by the Oxford scale. The break-up time of the tear film was longer in the group using lidocaine gel 2 % (20.35 ± 7.37 seconds) compared to lidocaine 5 % (19.75 ± 7.00 seconds).
Lidocaine gel 5 % showed an equal efficacy with longer lasting anesthetic effects in comparison to 2 %. There was no corneal toxicity at either concentration.
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