June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Comparative study between lidocaine gel 2% and 5% for ophthalmic procedures
Author Affiliations & Notes
  • Müller Gonçalves Urias
    Federal University of São Paulo, São Paulo, Brazil
  • Helio Francisco Shiroma
    Federal University of São Paulo, São Paulo, Brazil
  • Eduardo B Rodrigues
    Federal University of São Paulo, São Paulo, Brazil
  • Michel Eid Farah
    Federal University of São Paulo, São Paulo, Brazil
  • Footnotes
    Commercial Relationships Müller Urias, None; Helio Shiroma, None; Eduardo Rodrigues, None; Michel Eid Farah, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 1192. doi:https://doi.org/
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      Müller Gonçalves Urias, Helio Francisco Shiroma, Eduardo B Rodrigues, Michel Eid Farah; Comparative study between lidocaine gel 2% and 5% for ophthalmic procedures. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1192. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To compare the anesthetic efficacy of lidocaine gel 2% and 5% on the ocular surface in healthy subjects.

Methods: A prospective, randomized, double-blind study was carried out by spraying lidocaine gel, at a concentration of 2% or 5% in each eye, of a healthy reasearch group. The pain during instillation and conjunctival clamping were evaluated on the fifth and tenth minute after the application of the gel. The break-up time of the tear film was also measured and the degree of corneal conjunctival dyeing was rated according to the Oxford scale.

Results: Eighty eyes of 40 patients were evaluated. The groups were similar in gender, with a mean age of 48 ± 16.26 years. The pain caused by instillation was found to be higher in the group using lidocaine gel 5 % (p = 0.092). Pain recorded at conjunctival clamping was lower in lidocaine 5 % (p = 0.564) in both the fifth the tenth minute (p <0.001). The majority of patients (80 %) had no corneal conjunctival dyeing. They were classified in grades I (16.25 %) and II (3.75 %) by the Oxford scale. The break-up time of the tear film was longer in the group using lidocaine gel 2 % (20.35 ± 7.37 seconds) compared to lidocaine 5 % (19.75 ± 7.00 seconds).

Conclusions: Lidocaine gel 5 % showed an equal efficacy with longer lasting anesthetic effects in comparison to 2 %. There was no corneal toxicity at either concentration.

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