Vitreoretinal Interface Enhanced High Density Spectral Domain Optical Coherence Tomography in Age-Related Macular Degeneration

Abstract

Purpose: Vitreoretinal interface findings have been reported in several pathologies using Swept Source OCT (SS OCT). Enhanced High Density Spectral Domain Optical Coherence Tomography (EHD- SDOCT) has not been widely studied in eyes affected by Age-Related Macular Degeneration (AMD). The purpose of this retrospective, observational study was to report structural findings of vitreoretinal interface using EHD-SDOCT in eyes with AMD.

Methods: Optovue RTVue XR Avanti (Optovue Inc.) in Enhanced HD line mode was used in 22 patients (44 eyes) at Denver Health Medical Center with either dry or wet macular degeneration. The patients included were subjects with a previous diagnosis of AMD. The age ranged between 58 and 89 years with a mean age of 73 years. 9% of the patients were male.

Results: The EHD- SDOCT findings included retinal pigment epithelium disruptions, choroidal neovascularization, retinal thinning, intraretinal edema, subretinal fluid and drusen in the subjects eyes. Other non AMD related findings included visualization of the Cloquet's canal with or without a vitreous septum connecting to the posterior precortical vitreous pocket and presence of epiretinal membrane. We found that 22 eyes (50%) had wet AMD while the other half had dry AMD. Posterior Vitreous Detachment (PVD) was not observed in any of our patients. Not evaluable premacular vitreous configuration was present in 10 eyes (22%). Of the evaluable eyes, Partial PVD was observed in 27 out of 34 eyes (79.41%).

Conclusions: EHD-SDOCT demonstrated to be a useful tool when observing vitreoretinal interface in AMD patients. Complete PVD was absent in all of our cases. This is probably linked to the fact that EHD-SDOCT is associated with wide field imaging and a high-quality visualization of vitreoretinal interface.