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Jung Yeul Kim, Han-min Lee, Il-hwan Shin, Chang-Sik Kim; Thickness of the Macula, Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer in the Macular hole : The Repeatability Study of Spectral Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1212.
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© ARVO (1962-2015); The Authors (2016-present)
We measured the thickness of the ganglion cell inner-plexiform layer (GCIPL), macula and retinal nerve fiber layer(RNFL) using spectral domain optical coherence tomography(SD-OCT) in patients with idiopathic macular hole to analyze repeatability and for comparison with fellow eye.
We analyzed 82 patients who visited our retinal clinic. An experienced examiner obtained two consecutive measurements from a macular cube 512 × 128 scan using SD-OCT and optic disc cube 200 X 200 scan. The patients were divided into three groups according to macular hole size(group A macular hole size < 400 µm , group B 400 µm < macular hole size < 1200 µm, and group C macular hole size < 1200 µm). Repeatability was determined by comparing the thickness of GCIPL, macula and RNFL values with normal fellow eye.
The average central macular thickness in patients with macular hole was 339.9±92.3㎛ which is significantly thicker than the normal fellow eye which was 251.7±62.2 ㎛. The average thickness of GCIPL in patients with macular hole was significantly thinner at 57.6±22.5㎛, compared to normal fellow eye which was 77.6±12.7 ㎛. There were no significant differences among three groups in terms of the GCIPL thickness. There were no significant differences in terms of the average RNFL thickness(p>0.05).<br /> The intraclass correlation coefficient for macula, RNFL was 0.994 and 0.975 respectively in patients with macular hole, while ICC for GCIPL was measured as at 0.702. The measurement repeatability for macular, RNFL and GCIPL was high in the normal fellow eye.
The repeatability and the thickness of GCIPL measurements was lower in patients with macular hole. The impact of changes in macular shape caused by the macular hole should be taken into consideration when measuring GCIPL thickness in various eye diseases such as glaucoma and neuro-ophthalmology.
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