June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Long term outcomes of Ranibizumab treatment in patients with diabetic macular edema in clinical practice
Author Affiliations & Notes
  • Manar Addou Regnard
    Ophthalmology, Lariboisière Hospital, Paris, France
  • Aude Couturier
    Ophthalmology, Lariboisière Hospital, Paris, France
  • Rabih Hage
    Ophthalmology, Lariboisière Hospital, Paris, France
  • Ramin Tadayoni
    Ophthalmology, Lariboisière Hospital, Paris, France
  • Pascale G Massin
    Ophthalmology, Lariboisière Hospital, Paris, France
  • Footnotes
    Commercial Relationships Manar Addou Regnard, None; Aude Couturier, None; Rabih Hage, None; Ramin Tadayoni, None; Pascale Massin, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 1757. doi:https://doi.org/
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      Manar Addou Regnard, Aude Couturier, Rabih Hage, Ramin Tadayoni, Pascale G Massin; Long term outcomes of Ranibizumab treatment in patients with diabetic macular edema in clinical practice. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1757. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To evaluate long-term functional and anatomical outcomes of intravitreal injection of Ranibizumab to treat diabetic macular edema (DME) in clinical practice.

 
Methods
 

A retrospective monocentric study was performed on patients treated for DME by intravitreal injections of Ranibizumab between 2011 and 2014, with a follow up of at least 18 months. Data collected included baseline demographics (history of the diabetes, hemoglobin A1c level…) and ocular findings (initial and final visual acuity (VA), indirect biomicroscopy examination, retinal photographs, central macular thickness (CMT) on optical coherence tomography). Main outcome measures were mean change in VA and CMT at 18 and 24 months. Secondary outcome measures were number of injections during the follow-up and percentage of eyes in remission, defined by the absence of injection during the last 5 months of follow up with VA stability.

 
Results
 

Sixty eight (68) eyes of 49 patients were included. Mean duration of follow-up was 25,2 ± 6,1 months [range 18 - 40,6 months]. Mean initial VA letter score was 53,9 ± 15,7 [1 - 83] (snellen equivalent 20/80) and mean initial CMT was 533,9 ± 147,1 μm [279 - 987 μm]. Mean change in VA letter score was +8,5 ± 11,4 [-26 - +35 ETDRS] at month 18 and +9,4 ±11,3 [-14 - +34] at month 24. The mean change in CMT at month 18 and 24 was respectively -141,7 ± 144 µm [-672 - +239 µm] and -152,8 ± 153 [-671 - +163 µm]. The mean of number of intravitreal injections was 7,1 ± 1,3 (median = 7) from baseline to month 12 ; 2,4 ± 1,6 (median = 3) from months 12 to 18, and 1,8 ± 1,6 (median = 2) from months 18 to 24. At month 18, 19,1% of eyes (13/68 eyes) were considered in remission.<br />

 
Conclusions
 

Ranibizumab was effective in maintaining VA and CMT outcomes at month 18 and 24 in patients with DME in clinical practice, with a declining number of injections, confirming the results of randomized clinical trials.

 
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