June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Lymphatics and other vessels in human cornea
Author Affiliations & Notes
  • Vito Romano
    Royal Liverpool University Hospital, Liverpool, United Kingdom
  • Bernhard Steger
    Royal Liverpool University Hospital, Liverpool, United Kingdom
  • Yalin Zheng
    UNiversity of Liverpool, Liverpool, United Kingdom
  • Colin E Willoughby
    UNiversity of Liverpool, Liverpool, United Kingdom
  • Sajjad Ahmad
    UNiversity of Liverpool, Liverpool, United Kingdom
  • Stephen B Kaye
    UNiversity of Liverpool, Liverpool, United Kingdom
  • Footnotes
    Commercial Relationships Vito Romano, None; Bernhard Steger, None; Yalin Zheng, None; Colin Willoughby, None; Sajjad Ahmad, None; Stephen Kaye, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 1964. doi:
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    • Get Citation

      Vito Romano, Bernhard Steger, Yalin Zheng, Colin E Willoughby, Sajjad Ahmad, Stephen B Kaye; Lymphatics and other vessels in human cornea. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):1964.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract 
 
Purpose
 

To investigate corneal neovascular complexes (CoNV) in vivo for the presence of lymphatic vessels.

 
Methods
 

Patients with clinically recognizable corneal neovascularisation (CoNV) undergoing corneal angiography for fine needle diathermy were included. Each CoNV complex was imaged using slit lamp biomicroscopic photography, confocal, and fluorescein and indocyanine green angiography (FA and ICGA). Fluorescein dye leakage and uptake from the extravascular to the intravascular space was investigated determined using repeat angiography and subtraction analysis. Vessel parameters (area, diameter, branching, tortousity, flow) were analysed using in house software.

 
Results
 

11 patients, (7 males and 4 females, mean age 68 years; range 22 - 74 years) were included. Only vessels containing red blood cells were visible using colour or red free images. Additional vessels not containing cells were detected using confocal and angiography (mean diameter 10-20mm); often adjacent to larger venules.

 
Conclusions
 

Not all vessels in the cornea carry or only intermittently carry red blood cells. Imaging of CoNV complexes using confocal and angiography allowed the differentiation between vessels with red blood and other cell trafficking, and vessels with acellular flow. It is unclear whether these latter ‘plasma’ vessels are dual functional and serve as lymphatic type vessels. These vessels may be of importance in mediating inflammation and rejection.  

 
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