June 2015
Volume 56, Issue 7
ARVO Annual Meeting Abstract  |   June 2015
Differences in the sensitivity to myopia-inducing stimuli of young guinea pigs sourced from different colonies
Author Affiliations & Notes
  • Mariana Garcia
    Vision Science, University of California, Berkeley, Berkeley, CA
  • David Hammond
    Deakin University, Geelong, VIC, Australia
  • Christine Frances Wildsoet
    Vision Science, University of California, Berkeley, Berkeley, CA
  • Footnotes
    Commercial Relationships Mariana Garcia, None; David Hammond, None; Christine Wildsoet, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 2167. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Mariana Garcia, David Hammond, Christine Frances Wildsoet; Differences in the sensitivity to myopia-inducing stimuli of young guinea pigs sourced from different colonies. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):2167.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose: To characterize the responses of guinea pigs sourced from different breeding colonies to myopia-inducing stimuli using negative lens and form deprivation paradigms.

Methods: English Short Hair guinea pig breeders were obtained from a commercial vendor (Elm Hill Labs, Chelmsford, MA - designated “Elm Hill” guinea pigs) and from a University-based breeding colony (University of Auckland, NZ - designated “NZ” guinea pigs). Elm Hill guinea pig pups were fitted with either negative lenses (-10, -5, or 0 D) or diffusers at 10 days of age. NZ guinea pigs were fitted with diffusers at 7 days of age. Both sets of animals were treated for 4 weeks. Ocular axial lengths were measured twice a week using high frequency A-scan ultrasonography, cycloplegic refractions were measured on treatment days 0, 14, and 28, and behavioral visual acuity measured on treatment day 28.

Results: Elm Hill guinea pigs fitted with lenses exhibited minimal interocular differences in axial length and refractive error after 28 days of treatment; likewise, form deprivation (FD) failed to significantly affect the rate of ocular elongation or to induce a myopic shift in refractive error. Overall changes in interocular difference in axial length (treated minus control) were 0.03±0.1 mm for -10 D lenses, -0.20±0.43 mm for -5D lenses, -0.01±0.21 mm for 0 D lenses, and 0.07±0.16 mm for FD. Conversely, the NZ guinea pigs exhibited a 0.17±0.12 mm increase in interocular differences in axial length after 28 days of FD treatment.

Conclusions: A systematic study of the ocular growth responses of young guinea pigs to myopia-inducing stimuli revealed significant strain-related differences. These results point to genetically determined differences in the sensitivity of emmetropization mechanisms to visual manipulation, even within the same breed. Finally, this works suggests that research groups wishing to work with a guinea pig myopia model should carefully consider the source of their animals.


This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.