Abstract
Purpose:
Vldlr knockout mice is characterized by subretinal neovascularization which mimics wet age-related macular degeneration in human. The purpose of this study is to investigate the effects of two anti-VEGF agents, Conbercept and Ranibizumab on subretinal neovascularization in Vldlr knockout mice.
Methods:
Six vldlr knockout mice were treated with intravitreal administration of 10ug/1ul conbercept or 10ug/1ul Ranibizumab in the right eyes. The left eyes served as control. Fluorescein angiography was performed before, 3 days and 7 days after administration of drugs. The area of fluorescein leakage was quantified using Image J software and compared.
Results:
The area of subretinal neovascularization reduced to 73% and 36% in the eyes treated with Conbercept at 3 days and 7 days. The area of subretinal neovascularization in the eyes treated with Ranibizumab reduced to 42% and 33% at 3 and 7 days respectively.
Conclusions:
Both Conbercept and ranibizumab inhibits subretinal neovascularization in Vldlr knockout mice.