June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Meibomian gland dysfunction and hypercholesterolemia
Author Affiliations & Notes
  • Yousef A Alghamdi
    Ophthalmology, Bascom Palmer Eye Institute, Miami, FL
    Ophthalmology, Miami Veterans Administration Medical Center, Miami, FL
  • Nabeel M Shalabi
    Ophthalmology, Bascom Palmer Eye Institute, Miami, FL
    Ophthalmology, Miami Veterans Administration Medical Center, Miami, FL
  • Allison Louise McClellan
    Ophthalmology, Bascom Palmer Eye Institute, Miami, FL
    Ophthalmology, Miami Veterans Administration Medical Center, Miami, FL
  • Anat Galor
    Ophthalmology, Bascom Palmer Eye Institute, Miami, FL
    Ophthalmology, Miami Veterans Administration Medical Center, Miami, FL
  • Footnotes
    Commercial Relationships Yousef Alghamdi, None; Nabeel Shalabi, None; Allison McClellan, None; Anat Galor, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 2505. doi:https://doi.org/
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      Yousef A Alghamdi, Nabeel M Shalabi, Allison Louise McClellan, Anat Galor; Meibomian gland dysfunction and hypercholesterolemia. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):2505. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To study the relationship between meibomian gland parameters and systemic lipid levels in an elderly, predominantly male population.

Methods: Patients with normal eyelid and corneal anatomy were prospectively recruited from the Miami VAMC eye clinic. Patients underwent a complete ocular surface examination including assessment of meibomian gland (MG) parameters. The main outcome measures were the correlations between meibomian gland parameters and systemic lipid levels.

Results: The mean age of the 136 patients was 65 (standard deviation 11); 90% were male, 52% white, and 30% Hispanic. A large percentage of the population (86%, n=117) had abnormal MG parameters defined as a score of 2 or greater (in the more severely affected eye) on any of the studies MG parameters (by subtype: vascularity 19%, plugging 69%, drop-out 48%, abnormal quality 60%). All associations between MG parameters and systemic lipid layers (total cholesterol, high-density lipoprotein, low-density lipoprotein, triglycerides) were weak and most were not significant. The only significant association was a negative one between triglyceride levels and meibum quality (Spearman’s rho -0.19, p-value=0.03).

Conclusions: Meibomian gland dysfunction is a frequent finding in an elderly, predominantly male population and does not seem to be related to systemic lipid levels.

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