Purchase this article with an account.
Nallely Ramos-Betancourt, Laura Alejandra González-Dibildox, Carla Rocío Robles-Gutiérrez, Dalia Marylin Rojo-Zamudio, Jorge Ozorno-Zarate, Jaime D Martinez, Everardo Hernandez-Quintela; Correlation between Infrared Meibography and Ocular Surface Disease signs and symptoms. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):2510.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To determine the correlation between infrared meibography characteristics and ocular surface disease signs and symptoms.
Thirty-six eyes from 18 patients were included. Fourteen (77.8%) patients were female; mean age was 40.83 years old (+/- 17.2, range 21-82). All patients underwent Ocular Surface Disease Index (OSDI) and Dry Eye Questionnaire (DEQ-5) questionnaires. Corneal and conjunctival staining was evaluated by fluorescein and, lisamine green, then graded by the Oxford Schema. Tear Film Break Up Time (TFBUT), Schirmer I test with anesthesia and, margin lid characteristics were recorded. All patients were evaluated with an Infrared Meibography (Keratograph 4, OCULUS, Wetzlar, Germany). The following data was analyzed: meibomian gland area, meibomian gland area loss (MGAL), tortuosity and presence of white patches of upper and lower eyelid. Pearson and Spearman correlation coefficients were used as statistical analysis.
Mean OSDI score was 23.74 (+/-18.79, range 2.5-23.74), and mean DEQ-5 score 7.0 (+/-3.96, range 0-14). A positive correlation was found between: MGAL of upper lid and fluorescein corneal staining (r= 0.331, p = 0.048), MGAL of lower lid and TFBUT (upper lid r= -0.335, p = 0.046; lower lid r= -.342, p = 0.041), and MGAL and Schirmer test (upper lid r = -0.455, p = 0.007, lower lid r= -607, p= <0.001). Tortuosity was found in 36.1% of upper lid and 2.8% in lower lid. Two (5.6%) eyes have MGAL greater than a 33% in the upper lid, and 6 (16.7%) in the lower lid. No white patches were found in any patient. No correlation was found between symptoms (by OSDI and DEQ-5 questionnaires) and infrared Meibography characteristics (r = .120, p = .648, and r=.088, p = .737, respectively). Asymmetric disease by infrared Meibography was found in 38.8% (7) subjects.
At list a third of subjects had an asymmetric disease. Positive correlation was found between infrared meibography and ocular surface disease signs. No correlation was found between meibography and symptoms.
This PDF is available to Subscribers Only