June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
CFH, ARMS2, Dietary Zinc and Age-Related Macular Degeneration; a Population-based Assessment
Author Affiliations & Notes
  • Paul R Healey
    Ophthalmology, University of Sydney, Sydney, NSW, Australia
  • Jie Jin Wang
    Ophthalmology, University of Sydney, Sydney, NSW, Australia
  • George Burlutsky
    Ophthalmology, University of Sydney, Sydney, NSW, Australia
  • Caroline C W Klaver
    Department of Ophthalmology, Erasmus Medical Center, Rotterdam, Netherlands
  • Gabrielle HS Buitendijk
    Department of Ophthalmology, Erasmus Medical Center, Rotterdam, Netherlands
  • Victoria Flood
    Faculty of Health and Behavioural Sciences, University of Wollongong, Wollongong, NSW, Australia
  • Andrew JR White
    Ophthalmology, University of Sydney, Sydney, NSW, Australia
  • Gerald Liew
    Ophthalmology, University of Sydney, Sydney, NSW, Australia
  • Paulus T V M De Jong
    Netherlands Institute for Neuroscience, Amsterdam, Netherlands
  • Paul Mitchell
    Ophthalmology, University of Sydney, Sydney, NSW, Australia
  • Footnotes
    Commercial Relationships Paul Healey, None; Jie Jin Wang, None; George Burlutsky, None; Caroline Klaver, None; Gabrielle Buitendijk, None; Victoria Flood, None; Andrew White, None; Gerald Liew, None; Paulus De Jong, None; Paul Mitchell, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 2574. doi:https://doi.org/
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      Paul R Healey, Jie Jin Wang, George Burlutsky, Caroline C W Klaver, Gabrielle HS Buitendijk, Victoria Flood, Andrew JR White, Gerald Liew, Paulus T V M De Jong, Paul Mitchell; CFH, ARMS2, Dietary Zinc and Age-Related Macular Degeneration; a Population-based Assessment. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):2574. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To determine the effect of CFH and ARMS2 risk alleles on the relationship between dietary zinc intake and incident late-stage age-related macular degeneration (AMD) in well-defined, European-derived, population-based cohorts.

Methods: Participants from the Blue Mountains Eye Study (BMES) and Rotterdam Study (RS) had dietary zinc intake assessed by food frequency questionnaires and genotyping performed using an Illumina Human 670-Quadv1 custom array and TaqMan assays. The cumulative 15-year probability of late-stage AMD was calculated using logistic regression analysis adjusting for age and smoking and after testing for interactions. Zinc intake was assessed both as a categorical and continuous variable. Participants were divided into four genotype groups according to CFH (C) and ARMS2 (A) risk allele number (0, 1 or 2); Group 1 (C01, A0), Group 2 (C2, A0), Group 3 (C01, A12), Group 4 (C2, A12).

Results: A total of 5246 participants were studied. The frequencies of Groups 1, 2, 3 and 4 were 53.0%, 8.7%, 32.9%, 5.4% respectively in the BMES and 55.1%, 7.7%, 32.5%, 4.8% respectively in the RS. Mean zinc intake was 12mg/day and 10.6mg/day in the two population respectively, and not significantly different among genotype groups. The overall incidence of AMD was 5.0% and varied by genotype group, 2.7%, 8.2%, 6.2%, and 19.7% in Groups 1, 2, 3 and 4 respectively in a combined two-population dataset. After adjusting for age, smoking and zinc intake, AMD was 3.0, 2.5 and 11.8 times more likely in Groups 2, 3 and 4 compared with Group 1. Zinc intake was associated with a substantially reduced AMD incidence in Group 4 (per mg/day increase, OR 0.8, 95% CI 0.7-0.9, p=0.0042). Compared with the lowest quartile of zinc intake (7.5mg/day), those consuming the highest quartile (15.3mg/day) were 81% less likely to develop AMD (OR 0.19, 95% CI 0.06-0.64, p=0.0074). No statistically significant increase or decrease in AMD risk associated with dietary zinc intake levels was found in the other genotype groups.

Conclusions: The frequencies of CFH/ARMS2 risk genotypes vary in European-derived populations with the lowest risk genotype found in over 50% of populations. In the genotype group at highest risk of AMD, increased dietary zinc intake was associated with a substantial reduction in AMD risk, in a dose-dependent manner.

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