June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Met-analysis and Literature Review of the Efficacy and Safety of iStent in the Treatment of Open Angle Glaucoma
Author Affiliations & Notes
  • Yufeng (Nancy) Chen
    Schulich School of Medicine and Dentistry, London, ON, Canada
  • Yiannis Iordanous
    Schulich School of Medicine and Dentistry, London, ON, Canada
    Ivey Eye Institute, London, ON, Canada
  • Sangita Patel
    Macmaster, Hamilton, ON, Canada
  • Wendy Wang
    Schulich School of Medicine and Dentistry, London, ON, Canada
  • Cindy M L Hutnik
    Schulich School of Medicine and Dentistry, London, ON, Canada
    Ivey Eye Institute, London, ON, Canada
  • Monali Malvankar
    Schulich School of Medicine and Dentistry, London, ON, Canada
    Ivey Eye Institute, London, ON, Canada
  • Footnotes
    Commercial Relationships Yufeng (Nancy) Chen, None; Yiannis Iordanous, None; Sangita Patel, None; Wendy Wang, None; Cindy Hutnik, None; Monali Malvankar, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 2687. doi:https://doi.org/
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      Yufeng (Nancy) Chen, Yiannis Iordanous, Sangita Patel, Wendy Wang, Cindy M L Hutnik, Monali Malvankar; Met-analysis and Literature Review of the Efficacy and Safety of iStent in the Treatment of Open Angle Glaucoma. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):2687. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To perform a systematic review and meta-analysis to evaluate and quantify the effect and safety of iStent alone without concurrent phacoemulsication.

Methods: Systematic review was conducted by searching MEDLINE, EMBASE, CINAHL, Web of Science,Cochrane, and conference proceedings between January 1, 2000 and June 30, 2014. Records were retrieved and screened using EPPI-Reviewer 4 gateway. Meta-analysis was completed using STATA v. 13.0. For continuous scale outcomes, standardized mean difference (SMD) was calculated as the effect size. To test heterogeneity, statistics, Z-value, and χ2 statistics was computed. Based on heterogeneity, fixed-effect and random-effect models were developed. Sub-group analysis was performed based on the number of iStents implanted in an eye and the follow-up period to assess the influence on post-operative intra-ocular pressure (IOP) and number of topical glaucoma medications.

Results: Our search strategy identified 105 records from published literature and 9 records from grey literature. Eight studies (272 subjects) of iStent were included for quantitative synthesis. Meta-analysis results showed significant reduction in the post-operative IOP (SMD = -2.05, 95% CI: [-2.53, -1.57]) and topical glaucoma medications (SMD = -1.43, CI: [-1.92, -0.95]) after iStent implantation. Maximum reduction in IOP occurred at 6 to less than 12 months (SMD = -2.64, CI: [-3.36, -1.92]). IOP decreased with the number of iStents implanted, IOP decrease post one iStent was (SMD=-1.91, CI:[-2.14, -1.14]), post two iStents (SMD = -2.39, CI: [-4.09, -0.69]), and post three iStents (SMD = -4.26, CI: [-5.18, -3.33]). Decrease in topical glaucoma medications also correlated with number of istents implanted, with one iStent it was (SMD = -1.25, CI: [-1.94, -0.56]), with two iStents it was (SMD = -1.88, CI:[-2.20, -1.56]), and with three iStents it was (SMD = -2.00, CI:[-2.62, -1.38]). Most commonly reported complications post istent surgery is istent occlusion, iStent malposition, and hyphema although rate of occurrence differences depending on the study.

Conclusions: iStent alone without concurrent phacoemulsification is effective in both lowering IOP and in reducing dependency on glaucoma medications. Both IOP decrease and decrease in number of glaucoma medications correlates with the number of iStents implanted. There is lack of studies on complications post IStent insertion.

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