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ByungKun Lee, Chandrasekharan Krishnan, Woo Jhon Choi, Mehreen Adhi, Talisa de Carlo, Adam T Chin, Chen D Lu, Jay S Duker, Joel S Schuman, James G Fujimoto; Total Retinal Blood Flow Measurements with En Face Doppler Optical Coherence Tomography in Primary Open-Angle Glaucoma. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):2747. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
Total retinal blood flow (TRBF) measurement with en face Doppler optical coherence tomography (OCT) does not require vessel angle information and therefore enables fully automatic calculation of blood flow with improved measurement repeatability. High-speed SS-OCT imaging can resolve blood flow pulsatility, allowing accurate mean TRBF measurement. We investigate TRBF using en face Doppler OCT in patients with primary open-angle glaucoma (POAG).
TRBF was measured in one randomly selected eye for each of 13 patients with POAG (age 69.4±3.9yo) and 6 normal subjects (age 62.5±10.7yo) using a high-speed SS-OCT prototype operating at 400kHz axial scan rate and 1050nm wavelength. Volumetric data comprising 600×80 axial scans over a 1.5mm×2mm area at the optic disc was acquired at 7.1 volumes per second, fast enough to resolve flow pulsatility in the central retinal artery. The volume scan was repeated 24 times in 3.4 seconds of total acquisition time. Automatic software calculation of TRBF was implemented. Mean TRBF was calculated as the average of TRBF over the cardiac cycle.
Mean TRBF was 35.9±7.4μL/min in eyes with POAG and 42.0±8.7μL/min in normal eyes. The difference between the two groups was not statistically significant (P>0.05, one-tailed Welch's t-test). This differs from several previous reports where eyes with POAG exhibited significantly less TRBF than normal eyes.
En face Doppler OCT measurement of TRBF in patients with POAG and normal subjects was performed using a high-speed SS-OCT instrument. A statistically significant difference in TRBF was not observed between POAG and normals. TRBF may not be a sensitive diagnostic marker for detecting glaucoma because of the large variation in the normal population, although it may be useful for assessing progression. Functional flow response to stimulus may be a more sensitive marker which warrants further investigation.
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